Evaluation of Drug Trials in High-, Middle-, and Low-Income Countries and Local Commercial Availability of Newly Approved Drugs
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.7075
Abstract: Key Points Question How commonly are drugs commercially available in the countries where they were tested? Findings This cross-sectional study found that 5 years after their approval in the US, 15% of novel drugs (5… read more here.
Keywords: drug trials; evaluation drug; high middle; trials high ... See more keywords
Evaluation of drug resistance mutations in patients with chronic hepatitis B
Sign Up to like & getrecommendations! Published in 2018 at "Folia Microbiologica"
DOI: 10.1007/s12223-018-0650-z
Abstract: Mutations occurring in viral polymerase gene of hepatitis B virus (HBV) due to the use of nucleos(t)id analogs reduce the activity of the drugs by causing antiviral resistance. In this study, it was aimed to… read more here.
Keywords: drug resistance; evaluation drug; drug; resistance ... See more keywords
Evaluation of drug repositioning by molecular docking of pharmaceutical resources available in the Brazilian healthcare system against SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2021 at "Informatics in Medicine Unlocked"
DOI: 10.1016/j.imu.2021.100539
Abstract: In 2020 SARS-CoV-2 reached pandemic status, reaching Brazil in mid-February. As of now, no specific drugs for treating the disease are available. In this work, the possibility of interaction between SARS-CoV-2 viral proteins (open and… read more here.
Keywords: drug repositioning; system; evaluation drug; repositioning molecular ... See more keywords
The evaluation of drug-induced changes in left ventricular function in pentobarbital-anesthetized dogs.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2018.01.002
Abstract: INTRODUCTION The goal of this study was to determine whether assessment of myocardial contractility and hemodynamics in an anesthetized dog model, could consistently detect drug-induced changes in the inotropic state of the heart using drugs… read more here.
Keywords: induced changes; evaluation drug; changes left; drug induced ... See more keywords
Evaluation of drug interaction potential of zanubrutinib with cocktail probes representative of CYP3A4, CYP2C9, CYP2C19, P‐gp and BCRP
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.14707
Abstract: This study aims to assess the potential effects of zanubrutinib on the activity of cytochrome P450 (CYP) enzymes and drug transporter proteins using a cocktail probe approach. read more here.
Keywords: drug interaction; evaluation drug; interaction potential; drug ... See more keywords
Evaluation of Drug Susceptibility of Microorganisms in Odontogenic Inflammations and Dental Surgery Procedures Performed on an Outpatient Basis
Sign Up to like & getrecommendations! Published in 2019 at "BioMed Research International"
DOI: 10.1155/2019/2010453
Abstract: Bacterial infections are the most common cause of purulent soft tissue inflammations in the head and neck area. These bacteria are also responsible for the majority of inflammatory complications after third molar removal. The key… read more here.
Keywords: evaluation drug; gram negative; odontogenic inflammations; drug susceptibility ... See more keywords
Abstract A25: Evaluation of Drug Disposition in Supratentorial Ependymoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.pedca19-a25
Abstract: Introduction: The majority of pediatric supratentorial (ST) ependymomas (EPN) is driven by distinct gene fusions between C11orf95 and RELA. The resultant molecular group of ST-EPN-RELA tumors is characterized by constitutive activation of NF-κB signaling and… read more here.
Keywords: drug; epn rela; evaluation drug; drug disposition ... See more keywords