Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1.
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DOI: 10.1016/j.ejmech.2020.112338
Abstract: Histone modifying proteins, specifically histone deacetylases (HDACs) and bromodomains, have emerged as novel promising targets for anticancer therapy. In the current work, based on available crystal structures and docking studies, we designed dual inhibitors of… read more here.
Keywords: design synthesis; evaluation dual; biological evaluation; dual targeting ... See more keywords