Synthesis and Pharmacological Evaluation of Fluorinated Quinoxaline‐Based κ‐Opioid Receptor (KOR) Agonists Designed for PET Studies
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DOI: 10.1002/cmdc.202000502
Abstract: κ‐Opioid receptors (KORs) play a predominant role in pain alleviation, itching skin diseases, depression and neurodegenerative disorders such as multiple sclerosis. Therefore, imaging of KOR by a fluorinated PET tracer was envisaged. Two strategies were… read more here.
Keywords: kor; pharmacological evaluation; evaluation fluorinated; fluorinated quinoxaline ... See more keywords
Synthesis and evaluation of 3'-fluorinated 7-deazapurine nucleosides as antikinetoplastid agents.
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DOI: 10.1016/j.ejmech.2021.113290
Abstract: Kinetoplastid parasites are the causative agents of neglected tropical diseases with an unmet medical need. These parasites are unable to synthesize the purine ring de novo, and therefore rely on purine salvage to meet their… read more here.
Keywords: antikinetoplastid agents; deazapurine nucleosides; evaluation fluorinated; fluorinated deazapurine ... See more keywords