Evaluation of heteroatom-rich derivatives as antitubercular agents with InhA inhibition properties
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DOI: 10.1007/s00044-017-2064-x
Abstract: Two series of heterocyclic compounds derived from 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one (DHA) and 2-acetylbutyrolactone have been synthesized and characterized. The compounds were evaluated for their activities against Mycobacterium tuberculosis strain, and as inhibitors of InhA, a key enzyme… read more here.
Keywords: antitubercular agents; rich derivatives; agents inha; evaluation heteroatom ... See more keywords