Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs.
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DOI: 10.1021/acsmedchemlett.9b00372
Abstract: Focal adhesion kinase (FAK), a cytoplasmic protein tyrosine kinase, exerts kinase-dependent enzymatic functions and kinase-independent scaffolding functions, both of which are crucial in cancer development, early embryonic development, and reproduction. However, previous efforts for FAK… read more here.
Keywords: highly potent; design synthesis; fak; evaluation highly ... See more keywords
Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents
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DOI: 10.3390/pharmaceutics14061191
Abstract: Two different series of fifty-two compounds, based on 3′,4′,5′-trimethoxyaniline (7a–ad) and variably substituted anilines (8a–v) at the 7-position of the 2-substituted-[1,2,4]triazolo [1,5-a]pyrimidine nucleus, had moderate to potent antiproliferative activity against A549, MDA-MB-231, HeLa, HT-29 and… read more here.
Keywords: evaluation highly; synthesis biological; cell; highly active ... See more keywords