Biodistribution, pharmacokinetics and toxicity evaluation of mannosylated gelatin nanoparticles of linezolid for anti-tubercular therapy
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DOI: 10.1080/10667857.2020.1816021
Abstract: The present study explores the therapeutic potential of gelatin nanoparticles as a carrier for the delivery of linezolid, a repurposed drug for the treatment of Mycobactrium tuberculosis. However, ... read more here.
Keywords: biodistribution pharmacokinetics; toxicity evaluation; mannosylated gelatin; pharmacokinetics toxicity ... See more keywords
Synthesis and Immunological Evaluation of Mannosylated Desmuramyl Dipeptides Modified by Lipophilic Triazole Substituents
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DOI: 10.3390/ijms23158628
Abstract: Muramyl dipeptide (N-acetylmuramyl-L-alanyl-D-isoglutamine, MDP) is the smallest peptidoglycan fragment able to trigger an immune response by activating the NOD2 receptor. Structural modification of MDP can lead to analogues with improved immunostimulating properties. The aim of… read more here.
Keywords: lipophilic triazole; evaluation mannosylated; immunological evaluation; synthesis immunological ... See more keywords