Design, synthesis, biological evaluation, and molecular dynamics of novel cholinesterase inhibitors as anti‐Alzheimer's agents
Sign Up to like & getrecommendations! Published in 2019 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201800352
Abstract: A series of novel chroman‐4‐one derivatives were designed and synthesized successfully with good to excellent yield (3a–l). In addition, the obtained products were evaluated for their cholinesterase (ChE) inhibitory activities. The results show that among… read more here.
Keywords: design synthesis; cholinesterase; biological evaluation; molecular dynamics ... See more keywords
Evaluation of Molecular Fingerprints for Determining Dye Aggregation on Semiconductor Surfaces.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular informatics"
DOI: 10.1002/minf.202000062
Abstract: Dye aggregation plays an important role in determining the photovoltaic performance of dye sensitized solar cells. Compared with the spectra observed in solution, it is, apriori , difficult to ascertain whether a dye is likely… read more here.
Keywords: aggregation; semiconductor; dye aggregation; fingerprints determining ... See more keywords
Design, synthesis, biological evaluation and molecular modelling studies of indole glyoxylamides as a new class of potential pancreatic lipase inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.01.012
Abstract: A series of eighteen indole glyoxylamide analogues were synthesized, characterized and evaluated for their pancreatic lipase inhibitory activity. Porcine pancreatic lipase (Type II) was used with 4-nitrophenyl butyrate (as substrate) for the in vitro assay.… read more here.
Keywords: design synthesis; biological evaluation; pancreatic lipase; lipase ... See more keywords
Synthesis, biological evaluation, and molecular docking studies of deoxygenated C-glycosides as LpxC inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105403
Abstract: The bacterial deacetylase LpxC is a promising target for the development of novel antibiotics being selectively active against Gram-negative bacteria. In chiral pool syntheses starting from d- and l-ribose, a series regio- and stereoisomeric monohydroxytetrahydrofuran… read more here.
Keywords: biological evaluation; evaluation molecular; docking studies; studies deoxygenated ... See more keywords
Biochemical evaluation and molecular docking assessment of glucosamines from Neocarya macrophylla fruits against Naja nigricollis venom.
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate research"
DOI: 10.1016/j.carres.2021.108436
Abstract: Two new glucosamines, Microphyllose A and B were isolated from the chloroform fraction of Neocarya macrophylla fruit using flash column chromatography. The structures of these compounds were elucidated based on chemical tests and the analysis… read more here.
Keywords: nigricollis venom; evaluation molecular; naja nigricollis; neocarya macrophylla ... See more keywords
Synthesis, biological evaluation and molecular docking study of N-(2-methoxyphenyl)-6-((4-nitrophenyl)sulfonyl)benzamide derivatives as potent HIV-1 Vif antagonists.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.01.010
Abstract: Viral infectivity factor (Vif) is protective against APOBEC3G (A3G)-mediated viral cDNA hypermutations, and development of molecules that inhibit Vif mediated A3G degradation is a novel strategy for blocking HIV-1 replication. Through optimizations of the central… read more here.
Keywords: methoxyphenyl nitrophenyl; benzamide; biological evaluation; molecular docking ... See more keywords
Synthesis, biological evaluation and molecular docking of pyrimidine and quinazoline derivatives of 1,5-benzodiazepine as potential anticancer agents
Sign Up to like & getrecommendations! Published in 2020 at "Journal of King Saud University - Science"
DOI: 10.1016/j.jksus.2019.12.002
Abstract: Abstract A new series of Pyrimidine (A, D and F) and quinazoline (B, C and E) analogues of 1,5-benzodiazepines were prepared via its nitrile-derived amidoximes in and nitrilium ions, respectively using one pot Domino reaction… read more here.
Keywords: pyrimidine quinazoline; biological evaluation; evaluation molecular; synthesis biological ... See more keywords
Pharmacokinetic evaluation, molecular docking and in vitro biological evaluation of 1, 3, 4-oxadiazole derivatives as potent antioxidants and STAT3 inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical Analysis"
DOI: 10.1016/j.jpha.2018.12.002
Abstract: 1, 3, 4-Oxadiazole derivatives (4a–5f) were previously synthesized to investigate their anticancer properties. However, studies relating to their antioxidant potential and signal transducer and activator of transcription (STAT) inhibition have not been performed. We investigated… read more here.
Keywords: pharmacokinetic evaluation; oxadiazole derivatives; evaluation molecular; evaluation ... See more keywords
Synthesis, biological evaluation and molecular docking studies of novel 2-alkylthiopyrimidino-Tacrines as anticholinesterase agents and their DFT calculations
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.127902
Abstract: Abstract To search for effective and selective inhibitors of cholinesterases (AChE and BuChE), a series of poly-functionalized Tacrine-derived compounds specifically 2-(alkylthio)-4-aryl-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-5-amines were designed an synthesized via Friedlander reaction. The structures of the newly synthesized compounds… read more here.
Keywords: biological evaluation; evaluation molecular; docking studies; synthesis biological ... See more keywords
Synthesis, kinetic evaluation and molecular docking studies of donepezil-based acetylcholinesterase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131425
Abstract: Abstract In an effort to develop new therapeutic agents to treat Alzheimer's disease, a series of donepezil-based analogs were designed, synthesized using an environmentally friendly route, and biologically evaluated for their inhibitory activity against electric… read more here.
Keywords: kinetic evaluation; acetylcholinesterase; molecular docking; donepezil based ... See more keywords
Extent of Resection of Glioblastoma: A Critical Evaluation in the Molecular Era.
Sign Up to like & getrecommendations! Published in 2021 at "Neurosurgery clinics of North America"
DOI: 10.1016/j.nec.2020.09.006
Abstract: The work of modern neurosurgical glioma practice combines securing accurate diagnoses, under the 2016 revised World Health Organization (WHO) Classification of Tumors of the Central Nervous System, with an aggressive and safe surgical pursuit of… read more here.
Keywords: extent resection; resection glioblastoma; critical evaluation; molecular era ... See more keywords