Synthesis and biological evaluation of new coumarin derivatives as cytotoxic agents
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100029
Abstract: New coumarin derivatives 9a–f, 10a–e, and 11a–f were synthesized and evaluated for their cytotoxic activity against a human breast cancer cell line (MCF‐7). All compounds exhibited good activity in the nanomolar range, using doxorubicin and… read more here.
Keywords: new coumarin; biological evaluation; evaluation new; coumarin derivatives ... See more keywords
Evaluation of New Drugs for Asthma and COPD: Endpoints, Biomarkers and Clinical Trial Design.
Sign Up to like & getrecommendations! Published in 2017 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2016_70
Abstract: There remains a considerable need to develop novel therapies for patients with asthma and chronic obstructive pulmonary disease (COPD). The greatest challenge at the moment is measuring the effects of novel anti-inflammatory drugs, as these… read more here.
Keywords: evaluation new; copd endpoints; asthma copd; copd ... See more keywords
Evaluation of a new wireless technique for continuous electroencephalography monitoring in neurological intensive care patients
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Monitoring and Computing"
DOI: 10.1007/s10877-020-00533-8
Abstract: A novel wireless eight-channel electroencephalography (EEG) headset specially developed for ICUs was tested in regard of comparability with standard 10/20 EEG systems. The continuous EEG (cEEG) derivations via CerebAir EEG headset (Nihon Kohden Europe, Rosbach,… read more here.
Keywords: evaluation new; electroencephalography; wireless; new wireless ... See more keywords
Evaluation of new 99mTc-labeled HYNIC-bombesin analogue for prostate cancer imaging
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Radioanalytical and Nuclear Chemistry"
DOI: 10.1007/s10967-018-5819-z
Abstract: In this study, we introduce a new 99mTc-radiolabeled bombesin derivative for imaging of prostate cancer (PC). We used 6-hydrazinonicotinamide (HYNIC) as bi-functional chelating agent and tricine/ethylenediamine diacetic acid (EDDA) as an exchange co-ligands. Radiolabeling was achieved… read more here.
Keywords: bombesin; evaluation new; new 99mtc; prostate cancer ... See more keywords
Synthesis and antimicrobial evaluation of new glucosylimino thiazole derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-019-01617-2
Abstract: Abstractp-Sulphonic-N-propionyl aniline 3 was produced from sulphanilic acid with propionic acid under reflux for 2 h, then the compound 3 reacted with thionyl chloride and the corresponding imidoyl chloride 4 was obtained. When imidoyl chloride 4… read more here.
Keywords: antimicrobial evaluation; evaluation new; synthesis antimicrobial; new glucosylimino ... See more keywords
Synthesis, molecular docking studies, and antimicrobial evaluation of new structurally diverse ureas.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.03.024
Abstract: A series of new urea derivatives (3a-p) have been synthesized from readily available isocyanates and amines in good to high yields. All synthesized compounds were fully characterized using 1H NMR, 13C NMR, IR, and mass… read more here.
Keywords: docking studies; antimicrobial evaluation; evaluation new; studies antimicrobial ... See more keywords
Development and clinical evaluation of a new multiplex PCR assay for a simultaneous diagnosis of tuberculous and nontuberculous mycobacteria
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103527
Abstract: Background The prevalence of non-tuberculous mycobacteria (NTM) has been increasing worldwide in both developed and developing countries. NTM infection is clinically indistinguishable from tuberculosis and therefore poses significant challenges in patient management, especially in patients… read more here.
Keywords: development clinical; new multiplex; evaluation new; multiplex assay ... See more keywords
Synthesis and preliminary anticancer evaluation of new triazole bisphosphonate-based isoprenoid biosynthesis inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113241
Abstract: The synthesis of a new set of triazole bisphosphonates 8a-d and 9a-d presenting an alkyl or phenyl substituent at the C-4 or C-5 position of the triazole ring is described. These compounds have been evaluated… read more here.
Keywords: anticancer evaluation; new triazole; biosynthesis; evaluation new ... See more keywords
Performance evaluation of a new stepped solar still under the desert climatic conditions
Sign Up to like & getrecommendations! Published in 2018 at "Energy Conversion and Management"
DOI: 10.1016/j.enconman.2018.06.114
Abstract: Abstract This paper presents a new stepped solar still proposed to improve the daily productivity of the conventional basin type solar still (CSS). An internal Multi-Tray Evaporator (MTE) was integrated against the still rear-wall to… read more here.
Keywords: stepped solar; solar still; evaluation new; performance evaluation ... See more keywords
EVALUATION OF A NEW RADIATION PROTECTION TECHNOLOGY (CARDIO-TRAP®) IN TRANSRADIAL PERCUTANEOUS CORONARY INTERVENTION PROCEDURES
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(17)34754-x
Abstract: Background: Reduced risk of bleeding, reduced hospital stay, and increased comfort has increased the use of the transradial approach for percutaneous coronary procedures. However, risk of increased operator exposure to scatter radiation is a concern,… read more here.
Keywords: new radiation; evaluation new; radiation; protection technology ... See more keywords
Synthesis and Pharmacological Evaluation of New N-Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00149
Abstract: NLRP3 is involved in the pathophysiology of several inflammatory diseases. Therefore, there is high current interest in the clinical development of new NLRP3 inflammasome small inhibitors to treat these diseases. Novel N-sulfonylureas were obtained by… read more here.
Keywords: synthesis pharmacological; new sulfonylureas; pharmacological evaluation; nlrp3 inflammasome ... See more keywords