Design, synthesis, in silico and antiproliferative evaluation of novel pyrazole derivatives as VEGFR‐2 inhibitors
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DOI: 10.1002/ardp.201700234
Abstract: As the blockade of the VEGFR‐2 signaling pathway is a viable approach in cancer therapy, the present study focuses on a series of pyrazole based VEGFR‐2 inhibitors that were designed on the basis of the… read more here.
Keywords: design synthesis; evaluation novel; synthesis silico; vegfr inhibitors ... See more keywords
Synthesis, characterization, and biological evaluation of some novel Schiff bases as potential metabolic enzyme inhibitors
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DOI: 10.1002/ardp.202100430
Abstract: In this study, a series of novel Schiff base derivatives containing a pyrazolone ring (2a–e) were designed, successfully synthesized for the first time, and characterized by elemental analysis and some spectroscopic methods. These compounds were… read more here.
Keywords: schiff bases; evaluation novel; biological evaluation; novel schiff ... See more keywords
Synthesis and evaluation of novel xanthene‐based thiazoles as potential antidiabetic agents
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DOI: 10.1002/ardp.202200356
Abstract: A series of xanthene‐based thiazoles was synthesized and characterized by different scpectroscopic methods, i.e. Proton nuclear magnetic resonance (1H NMR), carbon nuclear magnetic resonance (13C NMR), infrared spectroscopy, carbon hydrogen nitrogen analysis, and X‐ray crystallography.… read more here.
Keywords: evaluation novel; xanthene based; novel xanthene; based thiazoles ... See more keywords
Synthesis, in vivo and in silico evaluation of novel 2,3‐dihydroquinazolin‐4(1H)‐one derivatives as potential anticonvulsant agents
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DOI: 10.1002/ddr.21506
Abstract: In light of the pharmacophoric structural requirements for achieving anticonvulsant activity, a series of N‐(1‐methyl‐4‐oxo‐2‐un/substituted‐1,2‐dihydroquinazolin‐3[4H]‐yl)benzamide (4a‐g) and N‐(1‐methyl‐4‐oxo‐2‐un/substituted‐1,2‐dihydroquinazolin‐3[4H]‐yl)‐2‐phenylacetamide (4h‐n) derivatives were synthesized in two steps starting from the reaction of N‐methyl isatoic anhydride with the… read more here.
Keywords: vivo silico; synthesis vivo; evaluation novel; dihydroquinazolin one ... See more keywords
Synthesis and biological evaluation of novel 5-substituted/unsubstituted triazolothiadiazines as tubulin depolymerizing and vascular disrupting agents with promising antitumor activity.
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DOI: 10.1002/ddr.22066
Abstract: A novel series of 5-substituted/unsubstituted [1,2,4]triazolo[3,4-b][1,3,4] thiadiazine compounds has been achieved successfully through chemoselective reduction of the C = N bond, based on our prior work. Initial biological evaluation illustrated that the most active derivative 7j exhibited… read more here.
Keywords: synthesis biological; evaluation novel; biological evaluation; activity ... See more keywords
Synthesis and Evaluation of Novel [1,2,4]Triazolo[1,5‐c]quinazoline Derivatives as Antibacterial Agents
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DOI: 10.1002/jhet.2979
Abstract: A series of new 2-aryl-5-methyl-[1,2,4]triazolo[1,5-c]quinazoline derivatives (5a–5g) have been synthesized by the reaction of 3-amino-2-methylquinazolin-4-(3H)-one (3) with aromatic nitriles in potassium tert-butoxide under reflux conditions. 3-Amino-2-methylquinazolin-4-(3H)-one (3) was synthesized by the reaction 2-methyl-4H-benzo[d][1,3]oxazin-4-one (2) with… read more here.
Keywords: triazolo quinazoline; synthesis evaluation; quinazoline derivatives; evaluation novel ... See more keywords
Clinical evaluation of a novel multipoint radiofrequency ablation device to treat chronic rhinitis
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DOI: 10.1002/lio2.1040
Abstract: Safety and efficacy of the NEUROMARK® system for treating chronic rhinitis. read more here.
Keywords: novel multipoint; rhinitis; evaluation novel; multipoint radiofrequency ... See more keywords
Synthesis and Antitumor Evaluation of Novel Hybrids of Phenylsulfonylfuroxan and Estradiol Derivatives
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DOI: 10.1002/open.201900228
Abstract: Abstract Fifteen novel furoxan‐based nitric oxide (NO) releasing hybrids of estradiol derivatives were synthesized and evaluated in vitro anti‐proliferative activity in MDA‐MB‐231, A2780, Hela and HUVEC cell lines. Most of them displayed potent anti‐proliferative effects. Among… read more here.
Keywords: antitumor evaluation; novel hybrids; estradiol derivatives; evaluation novel ... See more keywords
Antimicrobial evaluation of novel buccoadhesive films containing Myrrh extract
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DOI: 10.1007/s00289-017-1946-x
Abstract: This study describes the formulation of new buccoadhesive films containing Myrrh extract as a natural and safe antimicrobial agent to give a long local medication. Buccoadhesive films of Myrrh extract were developed using solvent evaporation… read more here.
Keywords: myrrh extract; buccoadhesive films; evaluation novel; antimicrobial evaluation ... See more keywords
Synthesis and evaluation of some novel 3-hetarylindole derivatives as antimicrobial and antioxidant agents
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DOI: 10.1007/s10593-018-2317-8
Abstract: In a continuation of our program to develop a new class of antimicrobial and antioxidant agents, 13 novel 3-substituted indole derivatives incorporating biologically active heterocycles were synthesized and evaluated for their in vitro antimicrobial activity.… read more here.
Keywords: novel hetarylindole; evaluation novel; antimicrobial antioxidant; antioxidant agents ... See more keywords
Synthesis and Bioactivity Evaluation of Novel N-Pyridylpyrazolemethanamine Derivatives
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DOI: 10.1007/s40242-018-8083-4
Abstract: To further explore the structure-activity relationship(SAR) of amide bridge moeity of anthranilic diamides derivatives, a series of N-pyridylpyrazole derivatives was designed, synthesized and their biological activities were evaluated. The chemical structures of novel target compounds… read more here.
Keywords: evaluation novel; novel pyridylpyrazolemethanamine; bioactivity evaluation; pyridylpyrazolemethanamine derivatives ... See more keywords