Development of a Phototoxicity Testing Strategy for Accurate Photosafety Evaluation of Pharmaceuticals Based on the Assessment of Possible Melanin-Binding Effects
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Toxicology"
DOI: 10.1177/1091581818777998
Abstract: Drug-induced phototoxicity occurs when drugs absorb natural sunlight, leading to chemical reactions causing cellular damage. Distribution to light-exposed tissues is critical and is enhanced by binding to melanin. The International Council on Harmonization S10 guidance… read more here.
Keywords: photosafety evaluation; evaluation pharmaceuticals; melanin; melanin binding ... See more keywords
Human induced pluripotent stem cell-derived hepatocytes and their culturing methods to maintain liver functions for pharmacokinetics and safety evaluation of pharmaceuticals.
Sign Up to like & getrecommendations! Published in 2020 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201021666200131123524
Abstract: Human hepatocytes are very important cell types for pharmacokinetics and the safety evaluation of pharmaceuticals. However, widely used primary hepatocytes with individual variations in liver function lose those functions rapidly in culture. Hepatic cell lines… read more here.
Keywords: evaluation pharmaceuticals; liver functions; safety evaluation; pharmacokinetics safety ... See more keywords