Design, synthesis and biological evaluation of pyrimidine-based derivatives as VEGFR-2 tyrosine kinase inhibitors.
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DOI: 10.1016/j.bioorg.2018.04.005
Abstract: Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in tumor angiogenesis, and inhibition of the VEGFR-2 signaling pathway has already become an attractive approach for cancer therapy. In this study, a novel pyrimidine-based… read more here.
Keywords: design synthesis; biological evaluation; evaluation pyrimidine; pyrimidine ... See more keywords