Design, synthesis and biological evaluation of quinazoline derivatives as potent and selective FGFR4 inhibitors.
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DOI: 10.1016/j.ejmech.2021.113794
Abstract: Aberrant activation of the fibroblast growth factor 19-fibroblast growth factor receptor 4 (FGF19-FGFR4) signaling pathway has been proved to promote hepatocellular carcinoma (HCC) proliferation. It is assumed that the first FGFR4 inhibitor BLU9931 did not… read more here.
Keywords: design synthesis; biological evaluation; evaluation quinazoline; quinazoline derivatives ... See more keywords