Evaluation of a Series of Wrong Intravitreous Injections.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2021.3311
Abstract: Importance This case series describes events associated with errors in intravitreous injections. Given the volume of injections performed worldwide, it is important to identify the factors associated with these wrong events to try to reduce… read more here.
Keywords: intravitreous injections; evaluation series; series; wrong intravitreous ... See more keywords
Design, Synthesis and Evaluation of a Series of Novel Super-long Acting DPP-4 Inhibitors for the Treatment of Type 2 Diabetes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00374
Abstract: In the present work, a novel series of trifluoromethyl substituted tetrahydropyran derivatives were rationally designed and synthesized as potent DPP-4 inhibitors with significantly improved duration time of action over current commercially available DPP-4 inhibitors. The… read more here.
Keywords: design synthesis; dpp inhibitors; evaluation series; dpp ... See more keywords
Evaluation of a Series of Lipidated Tucaresol Adjuvants in a Hepatitis C Virus Vaccine Model.
Sign Up to like & getrecommendations! Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.0c00413
Abstract: Hepatitis C virus (HCV) infections represent a global health challenge; however, developing a vaccine for treatment of HCV infection has remained difficult as heterogeneous HCV contains distinct genotypes, and each genotype contains various subtypes and… read more here.
Keywords: evaluation series; hcv; series lipidated; hepatitis virus ... See more keywords
Synthesis and Evaluation of a Series of New Bulleyaconitine A Derivatives as Analgesics
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DOI: 10.1021/acsomega.0c02944
Abstract: As a nonaddictive analgesic widely used in clinics, the LD50 of bulleyaconitine A is just only 0.92 mg/kg, which exhibits obvious toxicity. Therefore, 31 new non-natural C19-diterpenoid alkaloids (2a–w, 2′a–e, 3, 4a, and 4b) were… read more here.
Keywords: derivatives analgesics; new bulleyaconitine; bulleyaconitine derivatives; evaluation series ... See more keywords
Design, synthesis and biological evaluation of a series of dianilinopyrimidines as EGFR inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2046567
Abstract: Abstract This paper described our efforts to develop dianilinopyrimidines as novel EGFR inhibitors. All the target compounds were tested for inhibitory effects against wild type EGFR (EGFRwt) and three tumour cells, including A549, PC-3, and… read more here.
Keywords: design synthesis; synthesis biological; series dianilinopyrimidines; biological evaluation ... See more keywords