In vitro Antibacterial Evaluation of 1,2,4-Triazole Compounds Containing Purine Moiety
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DOI: 10.1007/s10600-017-2217-7
Abstract: 9H-[1,2,4]Triazolo[4,3-g]purin-5-amine (2) was synthesized by reaction of 6-hydrazinyl-7H-purin-2-amine (1a) with formic acid under reflux conditions. Treating compound 1a in ethanol with CS2 in the presence of KOH yielded 5-amino-3H-[1,2,4]triazolo[4,3-g]purine-3-thione (3). The new synthesized compounds were… read more here.
Keywords: containing purine; evaluation triazole; triazole compounds; compounds containing ... See more keywords
Synthesis and biological evaluation of 1,2,4-triazole derivatives as potential neuroprotectant against ischemic brain injury.
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DOI: 10.1016/j.ejmech.2020.112114
Abstract: A series of 1,2,4-triazole derivatives 1-14 was synthesized to investigate their neuroprotective effects and mechanisms of action. Compounds 5-11 noticeably protected PC12 cells from the cytotoxicity of H2O2 or sodium nitroprusside (SNP). Compound 11 was the… read more here.
Keywords: evaluation triazole; biological evaluation; triazole derivatives; compound ... See more keywords