Sizing clinical trials when comparing bivariate time-to-event outcomes.
Sign Up to like & getrecommendations! Published in 2017 at "Statistics in medicine"
DOI: 10.1002/sim.7225
Abstract: Clinical trials with multiple primary time-to-event outcomes are common. Use of multiple endpoints creates challenges in the evaluation of power and the calculation of sample size during trial design particularly for time-to-event outcomes. We present… read more here.
Keywords: time event; clinical trials; event; bivariate ... See more keywords
On selecting the critical boundary functions in group-sequential trials with two time-to-event outcomes.
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DOI: 10.1016/j.cct.2020.106244
Abstract: We investigate selection of critical boundary functions for testing the hypotheses of two time-to-event outcomes as both primary endpoints or a primary and a secondary endpoint in group-sequential clinical trials, where (1) the effect sizes… read more here.
Keywords: two time; time event; group sequential; critical boundary ... See more keywords
GRADE guidelines: 29. Rating the certainty in time-to-event outcomes - Study limitations due to censoring of participants with missing data in intervention studies.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2020.09.017
Abstract: OBJECTIVE To provide Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) guidance for the consideration of study limitations (risk of bias) due to missing participant outcome data for time-to-event outcomes in intervention studies. STUDY DESIGN… read more here.
Keywords: event outcomes; study limitations; time; time event ... See more keywords
Assessing the performance of the generalized propensity score for estimating the effect of quantitative or continuous exposures on survival or time-to-event outcomes
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DOI: 10.1177/0962280218776690
Abstract: Propensity score methods are frequently used to estimate the effects of interventions using observational data. The propensity score was originally developed for use with binary exposures. The generalized propensity score (GPS) is an extension of… read more here.
Keywords: time event; effect; propensity score; propensity ... See more keywords
Covariate-adjusted survival analyses in propensity-score matched samples: Imputing potential time-to-event outcomes
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DOI: 10.1177/0962280218817926
Abstract: Matching on an estimated propensity score is frequently used to estimate the effects of treatments from observational data. Since the 1970s, different authors have proposed methods to combine matching at the design stage with regression… read more here.
Keywords: time event; propensity score; propensity; event outcomes ... See more keywords
Challenges of modelling approaches for network meta-analysis of time-to-event outcomes in the presence of non-proportional hazards to aid decision making: Application to a melanoma network
Sign Up to like & getrecommendations! Published in 2022 at "Statistical Methods in Medical Research"
DOI: 10.1177/09622802211070253
Abstract: Background Synthesis of clinical effectiveness from multiple trials is a well-established component of decision-making. Time-to-event outcomes are often synthesised using the Cox proportional hazards model assuming a constant hazard ratio over time. However, with an… read more here.
Keywords: event outcomes; time event; time; network ... See more keywords