Oxidative events in a double helix system promote the formation of kinetically trapped G-quadruplexes
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DOI: 10.1093/nar/gkaf260
Abstract: Abstract Guanine-rich oligonucleotide sequences can adopt four-stranded G-quadruplex structures. These sequences are highly susceptible to oxidative damage due to the low redox potential of their constituent guanine nucleotides. Oxidative lesions of guanine residue exhibit perturbations… read more here.
Keywords: kinetically trapped; oxidative events; events double; helix system ... See more keywords