EVI1 protein interaction dynamics: targetable for therapeutic intervention?
Sign Up to like & getrecommendations! Published in 2021 at "Experimental hematology"
DOI: 10.1016/j.exphem.2021.12.398
Abstract: High expression of the transcriptional regulator EVI1 encoded at the MECOM locus at 3q26 is one of the most aggressive oncogenic drivers in acute myeloid leukaemia (AML) and carries a very poor prognosis. How EVI1… read more here.
Keywords: evi1; protein interaction; evi1 protein; therapeutic intervention ... See more keywords
The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25862-3
Abstract: Chromosomal rearrangements are a frequent cause of oncogene deregulation in human malignancies. Overexpression of EVI1 is found in a subgroup of acute myeloid leukemia (AML) with 3q26 chromosomal rearrangements, which is often therapy resistant. In… read more here.
Keywords: enhancer; super enhancer; site; ctcf ... See more keywords
Clinical features and prognostic implications of ecotropic viral integration site 1 (EVI1) in childhood acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Hematology and Oncology"
DOI: 10.1080/08880018.2022.2117881
Abstract: Abstract In contrast to the extensive knowledge on EVI1 in myeloid malignancies, few data are available on the EVI1 transcript in pediatric ALL. The purpose of this study was to examine the clinical and biological… read more here.
Keywords: childhood; leukemia; evi1 patients; significance ... See more keywords
Abstract B003: EVI1 oncogenic role in non-canonical AR driven lethal prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-b003
Abstract: Androgen receptor (AR) remains active in castration-resistant prostate cancer (CRPC), and AR cistrome can become extensively reprogrammed with disease progression. Recent findings from our group and others have shown an association with non-canonical AR signature… read more here.
Keywords: prostate cancer; role; non canonical; evi1 ... See more keywords
Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021015325
Abstract: Key Points A novel EVI1 splice isoform is frequently expressed in inv(3)/t(3;3) leukemia and drives myeloid transformation. Frequent SF3B1 mutations in inv(3)/t(3;3) leukemia generate a novel EVI1 isoform with an altered second zinc finger domain. read more here.
Keywords: evi1 splicing; splicing contributes; leukemia; evi1 ... See more keywords
EVI1 drives leukemogenesis through aberrant ERG activation.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2022016592
Abstract: Chromosomal rearrangements involving the MDS1 and EVI1 complex locus (MECOM) on chromosome 3q26 define an aggressive subtype of acute myeloid leukemia (AML) that is associated with chemotherapy resistance and dismal prognosis. Established treatment regimens commonly… read more here.
Keywords: erg; aml; functions evi1; evi1 ... See more keywords
EVI1 in Leukemia and Solid Tumors
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12092667
Abstract: Simple Summary Ecotropic viral integration site 1 (EVI1) is transcriptionally activated in a subset of myeloid leukemias. Since its discovery, other isoforms of EVI1 have been identified. It has been shown that EVI1 and its… read more here.
Keywords: solid tumors; leukemia solid; mds1 evi1; cancer ... See more keywords