The difficult balance between scientific evidence and clinical practice: the 2016 ESSKA meniscus consensus on the surgical management of degenerative meniscus lesions
Sign Up to like & getrecommendations! Published in 2017 at "Knee Surgery, Sports Traumatology, Arthroscopy"
DOI: 10.1007/s00167-017-4458-1
Abstract: evidence, they claimed that patients which were included in these RCT’s represent only a minority of those seeking advice for painful knees in association with DML. This is in accordance with the findings of ESSKA’s… read more here.
Keywords: balance scientific; difficult balance; evidence; scientific evidence ... See more keywords
Generating Evidence of Clinical Outcomes of Drug–Drug Interactions
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DOI: 10.1007/s40264-016-0496-8
Abstract: As prescription drug use is on the rise, new medications are entering the market each year, and individuals with multiple comorbid conditions are living longer, the potential for drug–drug interactions (DDIs) is increasing. It has… read more here.
Keywords: drug interactions; clinical outcomes; evidence; drug ... See more keywords
Targeting the PD-1/PD-L1 pathway in glioblastoma multiforme: Preclinical evidence and clinical interventions.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107403
Abstract: Glioblastoma multiforme (GBM), as one of the immunosuppressive and common intrinsic brain tumors in adults, remains an intractable malignancy to manage. Since the standard of care for treatment, which includes surgery and chemoradiation, has not… read more here.
Keywords: multiforme preclinical; glioblastoma multiforme; preclinical evidence; targeting pathway ... See more keywords
Heterogeneity in sepsis: new biological evidence with clinical applications
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DOI: 10.1186/s13054-019-2372-2
Abstract: This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2019. Further information about the Annual Update in… read more here.
Keywords: medicine; sepsis new; heterogeneity sepsis; evidence clinical ... See more keywords
Applying Evidence From Clinical Trials: Need for Pediatric Learning Health System Research
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DOI: 10.1542/peds.2017-3098
Abstract: * Abbreviations: MDD — : major depressive disorder PCOR — : Patient-Centered Outcomes Research RCT — : randomized controlled trial Nationally, the lifetime and 12-month prevalences of adolescent major depressive disorder (MDD) have been reported… read more here.
Keywords: research; evidence; clinical trials; health ... See more keywords
Nutraceutical Approach to Peripheral Neuropathies: Evidence from Clinical Trials.
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DOI: 10.2174/1389200218666171031145419
Abstract: BACKGROUND The etiopathogenetic mechanisms of peripheral neuropathies include genetic, traumatic, toxic, metabolic, infectious, nutritional, inflammatory and paraneoplastic causes. Their treatment should primarily address their contributing causes. However, symptomatic therapy is also key in these conditions,… read more here.
Keywords: peripheral neuropathies; approach peripheral; neuropathies evidence; clinical trials ... See more keywords