Cross‐sectional observational study of the availability of evidence supporting novel implantable devices used in gastrointestinal surgery
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Surgery"
DOI: 10.1002/bjs.10485
Abstract: Evidence supporting the implementation of novel surgical devices is unstandardized, despite recommendations for assessing novel innovations. This study aimed to determine the proportion of novel implantable devices used in gastrointestinal surgery that are supported by… read more here.
Keywords: evidence supporting; surgery; novel implantable; implantable devices ... See more keywords
Levels of evidence supporting drug, device, and other recommendations in the American Heart Association/American College of Cardiology guidelines.
Sign Up to like & getrecommendations! Published in 2020 at "American heart journal"
DOI: 10.1016/j.ahj.2020.05.003
Abstract: Clinical guideline documents reflect the evidence supporting clinical practice, but few recommendations in cardiovascular guidelines are supported by evidence from randomized controlled trials (RCTs), the highest level of evidence. Incentives for generating evidence from RCTs… read more here.
Keywords: guideline; evidence supporting; device recommendations; cardiology ... See more keywords
Temporal trends in evidence supporting novel drug target discovery.
Sign Up to like & getrecommendations! Published in 2025 at "Nature communications"
DOI: 10.1038/s41467-025-67180-y
Abstract: Over the past decade, about one-fifth of FDA-approved drugs each year involve novel mechanism-of-action human targets. Although riskier than modulating well-known targets, these therapies address unmet needs and strengthen sector innovation. The Open Targets Platform… read more here.
Keywords: novel drug; evidence supporting; target; evidence ... See more keywords
Evidence supporting oxidative stress in a moderately affected area of the brain in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-29770-3
Abstract: The pathogenesis of Alzheimer’s disease (AD) remains to be elucidated. Oxidative damage and excessive beta-amyloid oligomers are components of disease progression but it is unclear how these factors are temporally related. At post mortem, the… read more here.
Keywords: evidence supporting; alzheimer disease; supporting oxidative; brain ... See more keywords
Investigation assessing the publicly available evidence supporting postmarketing withdrawals, revocations and suspensions of marketing authorisations in the EU since 2012
Sign Up to like & getrecommendations! Published in 2018 at "BMJ Open"
DOI: 10.1136/bmjopen-2017-019759
Abstract: Objectives To assess the sources of publicly available evidence supporting withdrawal, revocation or suspension of marketing authorisations (‘regulatory actions’) due to safety reasons in the EU since 2012 and to investigate the time taken since… read more here.
Keywords: marketing authorisations; evidence supporting; since 2012; publicly available ... See more keywords
Evidence Supporting LI-RADS Major Features for CT- and MR Imaging-based Diagnosis of Hepatocellular Carcinoma: A Systematic Review.
Sign Up to like & getrecommendations! Published in 2018 at "Radiology"
DOI: 10.1148/radiol.2017170554
Abstract: The Liver Imaging Reporting and Data System (LI-RADS) standardizes the interpretation, reporting, and data collection for imaging examinations in patients at risk for hepatocellular carcinoma (HCC). It assigns category codes reflecting relative probability of HCC… read more here.
Keywords: hepatocellular carcinoma; evidence supporting; hcc; supporting rads ... See more keywords
What Is the Evidence Supporting Osteobiologic Use in Revision Anterior Cervical Discectomy and Fusion?
Sign Up to like & getrecommendations! Published in 2024 at "Global Spine Journal"
DOI: 10.1177/21925682221133751
Abstract: Study design Systematic literature review Objective To analyze the literature and describe the evidence supporting osteobiologic use in revision anterior cervical discectomy and fusion (ACDF) surgery. Methods A systematic search of PubMed/MEDLINE, EMBASE, Cochrane library,… read more here.
Keywords: osteobiologic use; revision; evidence supporting; use revision ... See more keywords
Genetic Evidence Supporting a Causal Role of Snoring in Erectile Dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.896369
Abstract: Background The association between snoring and erectile dysfunction (ED) is inconsistent in multiple observational studies. To clarify the causal association of snoring on ED, we performed this two-sample Mendelian randomization study. Materials and Methods The… read more here.
Keywords: causal role; supporting causal; evidence supporting; erectile dysfunction ... See more keywords
Genetic Evidence Supporting the Repurposing of mTOR Inhibitors for Reducing BMI
Sign Up to like & getrecommendations! Published in 2025 at "Biomedicines"
DOI: 10.3390/biomedicines13040839
Abstract: Background: Although mTOR has long been regarded as a promising target for cancer treatment, the efficacy of mTOR inhibitors in most clinical trials has been rather limited. Nevertheless, their favorable safety profile has opened up… read more here.
Keywords: supporting repurposing; genetic evidence; evidence supporting; bmi ... See more keywords
Evidence Supporting a Role of Alternative Splicing Participates in Melon (Cucumis melo L.) Fruit Ripening
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25115886
Abstract: One key post-transcriptional modification mechanism that dynamically controls a number of physiological processes in plants is alternative splicing (AS). However, the functional impacts of AS on fruit ripening remain unclear. In this research, we used… read more here.
Keywords: alternative splicing; fruit ripening; evidence supporting; fruit ... See more keywords