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Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01701-7
Abstract: Hepatocellular carcinoma (HCC) patients have low 5-year survival due to the delayed diagnosis, so it is necessary to develop an alternative treatment. Preferentially expressed antigen of melanoma (PRAME) has a high expression in HCC patients,…
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Keywords:
growth;
prame;
prame expression;
hepg2 cells ... See more keywords
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Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-2956-6
Abstract: The aim of this study is to investigate the effect of evodiamine on fibroblast activation in cardiac fibroblasts and endothelial to mesenchymal transition (EndMT) in human umbilical vein endothelial cells (HUVECs). Neonatal rat cardiac fibroblasts…
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Keywords:
endothelial mesenchymal;
huvecs;
cardiac fibroblasts;
activation ... See more keywords
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Published in 2019 at "Human Cell"
DOI: 10.1007/s13577-019-00238-4
Abstract: Chemotherapy-induced neuropathic pain (CINP) is a common and debilitating side effect of cancer treatment. Evodiamine, a major effective compound isolated from Evodia rutaecarpa, has been associated with anti-inflammatory and anti-nociceptive effects, an important therapeutic strategy…
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Keywords:
paclitaxel induced;
induced neuropathic;
neuropathic pain;
evodiamine ... See more keywords
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Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-29281-1
Abstract: Evodiamine, a bioactive alkaloid from the fruits of the traditional Chinese medicine Evodia rutaecarpa (Juss.) Benth. (Fructus Evodiae, Wuzhuyu), recently gained attention as a dietary supplement for weight loss and optimization of lipid metabolism. In…
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Keywords:
target evodiamine;
novel interactomics;
cholesterol;
evodiamine ... See more keywords
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Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc00434c
Abstract: Efficient access to evodiamine and its analogues is presented via Lewis acid catalysis. In this reaction, three chemical bonds and two heterocyclic-fused rings are constructed in one step. The reaction shows good functional group tolerance…
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Keywords:
concise synthesis;
biological study;
evodiamine;
synthesis biological ... See more keywords
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Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2036767
Abstract: Abstract Context Patients with non-alcoholic steatohepatitis (NASH) may have a simultaneous intake of pravastatin and evodiamine-containing herbs. Objective The effect of evodiamine on the pharmacokinetics of pravastatin and its potential mechanisms were investigated in NASH…
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Keywords:
non alcoholic;
evodiamine decreased;
evodiamine;
pravastatin ... See more keywords
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Published in 2022 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmac062
Abstract: A phenyl-based monolithic adsorbent was prepared in a 50-mm-long stainless steel tube, which was initiated by the redox system, using ethylene glycol phenyl ether acrylate as the monomer and ethylene glycol dimethacrylate as the crosslinker.…
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Keywords:
spe;
evodiamine;
extraction;
evodiamine euodia ... See more keywords
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Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00290
Abstract: Evodiamine is a major ingredient of the plant Evodia rutaecarpa, which has long been used for treating infection-related diseases including diarrhea, beriberi and oral ulcer, but the underlying mechanism is unclear. Here we aimed to…
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Keywords:
inflammasome activation;
tubulin acetylation;
activation;
nlrp3 inflammasome ... See more keywords
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Published in 2022 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb44090298
Abstract: Evodiamine isolated from Evodia rutaecarpa has been known to have anti-tumor activity against various cancer cell types. Although there have been reports showing the inhibitory effect of evodiamine on cell survival of gastric cancer cell,…
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Keywords:
evodiamine;
cancer;
apoptosis;
fak akt ... See more keywords
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Published in 2023 at "Life"
DOI: 10.3390/life13020578
Abstract: Alzheimer’s disease is an irreversible neurological disorder for which there are no effective small molecule therapeutics. A phosphodiesterase 5 (PDE5) inhibitor is a candidate medicine for the treatment of Alzheimer’s disease. Rutaecarpine, an indole alkaloid…
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Keywords:
evodiamine;
complex pde5;
molecular dynamics;
pde5 evodiamine ... See more keywords