Evodiamine-Inspired Topoisomerase-Histone Deacetylase Dual Inhibitors: Novel Orally Active Antitumor Agents for Leukemia Therapy.
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DOI: 10.1021/acs.jmedchem.1c02026
Abstract: On the basis of the synergism of topoisomerase (Top) and histone deacetylase (HDAC) inhibitors in antitumor therapy, a series of novel Top/HDAC dual inhibitors were designed and synthesized by the pharmacophore fusion strategy. After systematic… read more here.
Keywords: histone deacetylase; orally active; antitumor; dual inhibitors ... See more keywords