Straightforward synthesis, characterization, and cytotoxicity evaluation of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones
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DOI: 10.1080/10286020.2018.1540599
Abstract: Abstract Dozens of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones were synthesized in a straightforward method by condensation of substituted 2H-thieno[2,3-d][1, 3]oxazine-2,4(1H)-diones or N-methyl-2H-thieno[2,3-d][1, 3]oxazine-2,4(1H)-dione with 3,4-dihydro-β-carbolines. In vitro cytotoxic assay discovered that compounds 9a,… read more here.
Keywords: thieno pyrimidinones; natural alkaloid; hybrids natural; alkaloid evodiamine ... See more keywords
Evodiamine and Rutaecarpine as Potential Anticancer Compounds: A Combined Computational Study
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DOI: 10.3390/ijms231911513
Abstract: Evodiamine (EVO) and rutaecarpine (RUT) are the main active compounds of the traditional Chinese medicinal herb Evodia rutaecarpa. Here, we fully optimized the molecular geometries of EVO and RUT at the B3LYP/6-311++G (d, p) level… read more here.
Keywords: rutaecarpine potential; evodiamine rutaecarpine; top1; anticancer ... See more keywords