Identification of evodiamine and rutecarpine as novel TMEM16A inhibitors and their inhibitory effects on peristalsis in isolated Guinea-pig ileum.
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DOI: 10.1016/j.ejphar.2021.174340
Abstract: The transmembrane member 16A (TMEM16A)-encoded Ca2+-activated Cl- channel (CaCC) is expressed in interstitial cells of Cajal (ICCs) and involved in the generation of the slow-wave currents of gastrointestinal (GI) smooth muscles. TMEM16A modulators have been… read more here.
Keywords: inhibitory effects; tmem16a; evodiamine rutecarpine; tmem16a inhibitors ... See more keywords