Directed evolution of adenine base editors with increased activity and therapeutic application
Sign Up to like & getrecommendations! Published in 2020 at "Nature Biotechnology"
DOI: 10.1038/s41587-020-0491-6
Abstract: The foundational adenine base editors (for example, ABE7.10) enable programmable A•T to G•C point mutations but editing efficiencies can be low at challenging loci in primary human cells. Here we further evolve ABE7.10 using a… read more here.
Keywords: base editors; adenine base; directed evolution; evolution adenine ... See more keywords