Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.
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DOI: 10.1021/acs.jmedchem.9b01582
Abstract: Dysregulation of translation initiation factor 4E (eIF4E) activity occurs in various cancers. Mitogen-activated protein kinase (MAPK) interacting kinases 1 and 2 (MNK1 and MNK2) play a fundamental role in activation of eIF4E. Structure-activity relationship-driven expansion… read more here.
Keywords: interacting kinases; fragment hits; stepwise evolution; evolution fragment ... See more keywords