Clonal evolution in healthy and premalignant tissues: implications for early cancer interception strategies.
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DOI: 10.1158/1940-6207.capr-22-0469
Abstract: Histologically normal human tissues accumulate significant mutational burden with age. The extent and spectra of mutagenesis are comparable both in rapidly proliferating and post-mitotic tissues and in stem cells compared to their differentiated progeny. Some… read more here.
Keywords: evolution healthy; clonal evolution; healthy premalignant; histologically normal ... See more keywords