An evolution-inspired strategy to design disulfide-rich peptides tolerant to extensive sequence manipulation
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Science"
DOI: 10.1039/d1sc02952e
Abstract: Natural disulfide-rich peptides (DRPs) are valuable scaffolds for the development of new bioactive molecules and therapeutics. However, there are only a limited number of topologically distinct DRP folds in nature, and most of them suffer… read more here.
Keywords: evolution inspired; strategy design; disulfide; disulfide rich ... See more keywords
Evolution-inspired engineering of nonribosomal peptide synthetases
Sign Up to like & getrecommendations! Published in 2024 at "Science"
DOI: 10.1126/science.adg4320
Abstract: Many clinically used drugs are derived from or inspired by bacterial natural products that often are produced through nonribosomal peptide synthetases (NRPSs), megasynthetases that activate and join individual amino acids in an assembly line fashion.… read more here.
Keywords: evolution inspired; peptide synthetases; engineering; biology ... See more keywords