Diversity oriented biosynthesis via accelerated evolution of modular gene clusters
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DOI: 10.1038/s41467-017-01344-3
Abstract: Erythromycin, avermectin and rapamycin are clinically useful polyketide natural products produced on modular polyketide synthase multienzymes by an assembly-line process in which each module of enzymes in turn specifies attachment of a particular chemical unit.… read more here.
Keywords: accelerated evolution; evolution; polyketide synthase; evolution modular ... See more keywords