The effect of spatiotemporal antibiotic inhomogeneities on the evolution of resistance.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2019.110077
Abstract: Combating the evolution of widespread antibiotic resistance is one of the most pressing challenges facing modern medicine. Recent research has demonstrated that the evolution of pathogens with high levels of resistance can be accelerated by… read more here.
Keywords: effect spatiotemporal; evolution; evolution resistance; spatiotemporal antibiotic ... See more keywords
The evolution of resistance and tolerance as cancer defences
Sign Up to like & getrecommendations! Published in 2019 at "Parasitology"
DOI: 10.1017/s0031182019001501
Abstract: Abstract Although there is a plethora of cancer associated-factors that can ultimately culminate in death (cachexia, organ impairment, metastases, opportunistic infections, etc.), the focal element of every terminal malignancy is the failure of our natural… read more here.
Keywords: evolution resistance; tolerance cancer; cancer;
Evolution of resistance (R) gene specificity.
Sign Up to like & getrecommendations! Published in 2022 at "Essays in biochemistry"
DOI: 10.1042/ebc20210077
Abstract: Plant resistance (R) genes are members of large gene families with significant within and between species variation. It has been hypothesised that a variety of processes have shaped R gene evolution and the evolution of… read more here.
Keywords: gene; gene specificity; evolution resistance;
Rotation of Multiple Single-Gene Transgenic Crops Did Not Slow the Evolution of Resistance to Cry1F or Cry1Ie in Ostrinia furnacalis
Sign Up to like & getrecommendations! Published in 2023 at "Insects"
DOI: 10.3390/insects14010074
Abstract: Simple Summary Delaying or preventing the evolution of resistance to Bacillus thuringiensis (Bt) toxins produced by transgenic crops in insect pests is a major challenge for agriculture. A simulation model suggested that the rotation of… read more here.
Keywords: evolution resistance; rotation; resistance; cry1f cry1ie ... See more keywords
Genetic determinants facilitating the evolution of resistance to carbapenem antibiotics
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.67310
Abstract: In this era of rising antibiotic resistance, in contrast to our increasing understanding of mechanisms that cause resistance, our understanding of mechanisms that influence the propensity to evolve resistance remains limited. Here, we identified genetic… read more here.
Keywords: evolution resistance; resistance; genetic determinants; carbapenem ... See more keywords