Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202507533
Abstract: Metastasis remains the leading cause of cancer‐related mortality, yet effective interventions against KRASG12C/D driven lung adenocarcinoma metastasis ared limited. In this study, using KRASG12D/–;TP53–/–;COA4–/– transgenic mice, clinical specimens, organoid models, RNA sequencing, xenograft assays, and… read more here.
Keywords: coa4 driven; evolutionarily conserved; kras mutant; metastasis dual ... See more keywords
The Evolutionarily Conserved TPM1 Super-Enhancer Drives Skeletal Muscle Regeneration via Mechanotransduction Signaling.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202514271
Abstract: Super-enhancers (SEs) are critical epigenetic regulators of tissue regeneration, yet their interplay with cellular biomechanics during myogenic differentiation remains unexplored. Here, the TPM1 locus, encoding a core actin-stabilizing protein essential for skeletal muscle regeneration, harbors… read more here.
Keywords: skeletal muscle; muscle; muscle regeneration; evolutionarily conserved ... See more keywords
Oxytocin‐like receptor expression in evolutionarily conserved nodes of a vocal network associated with male courtship in a teleost fish
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25257
Abstract: Neuropeptides, including oxytocin‐like peptides, are a conserved group of hormones that regulate a wide range of social behaviors, including vocal communication. In the current study, we evaluate whether putative brain sites for the actions of… read more here.
Keywords: poa; evolutionarily conserved; oxytocin like; male courtship ... See more keywords
The Stress-Responding miR-132-3p Shows Evolutionarily Conserved Pathway Interactions
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0515-z
Abstract: MicroRNAs (miRNAs) are small non-coding RNA chains that can each interact with the 3′-untranslated region of multiple target transcripts in various organisms, humans included. MiRNAs tune entire biological pathways, spanning stress reactions, by regulating the… read more here.
Keywords: mir 132; evolutionarily conserved; stress related; stress ... See more keywords
Lhx2, an evolutionarily conserved, multifunctional regulator of forebrain development
Sign Up to like & getrecommendations! Published in 2018 at "Brain research"
DOI: 10.1016/j.brainres.2018.02.046
Abstract: A hundred years after Lhx2 ortholog apterous was identified as a critical regulator of wing development in Drosophila, LIM-HD gene family members have proved to be versatile and powerful components of the molecular machinery that… read more here.
Keywords: forebrain; evolutionarily conserved; lhx2 evolutionarily; factor ... See more keywords
NOTCH signaling: Journey of an evolutionarily conserved pathway in driving tumor progression and its modulation as a therapeutic target.
Sign Up to like & getrecommendations! Published in 2021 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2021.103403
Abstract: Notch signaling, an evolutionarily conserved signaling cascade, is critical for normal biological processes of cell differentiation, development, and homeostasis. Deregulation of the Notch signaling pathway has been associated with tumor progression. Thus, Notch presents as… read more here.
Keywords: tumor progression; notch signaling; notch; evolutionarily conserved ... See more keywords
The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties
Sign Up to like & getrecommendations! Published in 2019 at "Translational Oncology"
DOI: 10.1016/j.tranon.2018.09.001
Abstract: The oncogene ERG encodes an ETS family transcription factor and is implicated in blood, vascular, and bone development and in prostate, blood, and bone cancer. The ERG gene is alternatively spliced; of particular interest is… read more here.
Keywords: evolutionarily conserved; erg oncogenic; exon; cassette exon ... See more keywords
Ubiquitin-Proteasome System Regulation of an Evolutionarily Conserved RNA Polymerase II-Associated Factor 1 Involved in Pancreatic Oncogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00865
Abstract: The evolutionarily conserved RNA polymerase II-associated factor 1 (Paf1) from yeast to humans regulates transcription and associated processes, and thus, malfunctions and/or misregulations of Paf1 are associated with cellular pathologies. Indeed, Paf1 (also known as… read more here.
Keywords: evolutionarily conserved; rna polymerase; factor; conserved rna ... See more keywords
Proteasome associated function of UCH37 is evolutionarily conserved in Plasmodium parasites
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-80433-y
Abstract: Ubiquitin C-terminal hydrolase 37 (UCH37 also known as UCHL5) is a conserved deubiquitinating enzyme (DUB) with dual roles in proteasomal degradation and chromatin remodeling in humans. Its Plasmodium falciparum ortholog, PfUCH37, is unusual in that… read more here.
Keywords: associated function; conserved plasmodium; proteasome associated; function uch37 ... See more keywords
The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2112225119
Abstract: Significance The hypocretin (Hcrt, also known as orexin) neuropeptides regulate sleep and wake stability, and disturbances of Hcrt can lead to sleep disorders. MicroRNAs (miRNAs) are short noncoding RNAs that fine-tune protein expression levels, and… read more here.
Keywords: sleep wake; conserved mirna; mirna 137; mir 137 ... See more keywords
TMEM63A, associated with hypomyelinating leukodystrophies, is an evolutionarily conserved regulator of myelination
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2507354122
Abstract: Significance Leukodystrophies are genetic disorders caused by deficient myelination in the central nervous system and are associated with debilitating neurological symptoms and motor defects. Human mutations in the mechanosensitive ion channel, TMEM63A, have been linked… read more here.
Keywords: leukodystrophies evolutionarily; myelination; hypomyelinating leukodystrophies; evolutionarily conserved ... See more keywords