Evolutionary conservation of amino acids contributing to the protein folding transition state
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.27060
Abstract: The question of whether amino acids critical to protein folding kinetics are evolutionarily conserved has been investigated intensively in the past, but no consensus has yet been reached. Recently, we have demonstrated that the transition… read more here.
Keywords: amino acids; conservation amino; state; evolutionary conservation ... See more keywords
Evolutionary conservation and positive selection of influenza A nucleoprotein CTL epitopes for universal vaccination
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27662
Abstract: Influenza (flu) infection is a leading cause of respiratory diseases and death worldwide. Although seasonal flu vaccines are effective at reducing morbidity and mortality, such effects rely on the odds of successful prediction of the… read more here.
Keywords: evolutionary conservation; vaccination; positive selection; influenza ... See more keywords
Evolutionary conservation of EF-hand ΙΙ loop in aequorin: Priority of intensity to decay rate in bioluminescence emission.
Sign Up to like & getrecommendations! Published in 2017 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2017.09.018
Abstract: As a Ca2+-regulated photoprotein, aequorin (Aeq) contains four EF-hand motifs, the second one lacks the standard sequence for Ca2+ coordination and doesn't bind to Ca2+. Here, we replaced this loop with a functional loop. According… read more here.
Keywords: decay rate; intensity; hand; rate ... See more keywords
Evolutionary conservation of transferrin genomic organization and expression characterization in seven freshwater turtles.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.10.168
Abstract: Serum transferrin (tf), encoding an iron-binding glycoprotein, has been revealed to play important roles in iron transportation and immune response, and it also has been demonstrated to be valuable for phylogenetic analysis in vertebrates. However,… read more here.
Keywords: seven freshwater; expression; transferrin genes; evolutionary conservation ... See more keywords
Evolutionary conservation of influenza A PB2 sequences reveals potential target sites for small molecule inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "Virology"
DOI: 10.1016/j.virol.2017.06.009
Abstract: The influenza A basic polymerase protein 2 (PB2) functions as part of a heterotrimer to replicate the viral RNA genome. To investigate novel PB2 antiviral target sites, this work identified evolutionary conserved regions across the… read more here.
Keywords: evolutionary conservation; pb2; target sites; conservation influenza ... See more keywords
Comprehensive list of SUMO targets in Caenorhabditis elegans and its implication for evolutionary conservation of SUMO signaling
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-19424-9
Abstract: Post-translational modification by small ubiquitin-related modifier (SUMO) is a key regulator of cell physiology, modulating protein-protein and protein-DNA interactions. Recently, SUMO modifications were postulated to be involved in response to various stress stimuli. We aimed… read more here.
Keywords: caenorhabditis elegans; sumo targets; stress; evolutionary conservation ... See more keywords
Evolutionary Conservation of MKRN3 and Other Makorins and Their Roles in Puberty Initiation and Endocrine Functions.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in reproductive medicine"
DOI: 10.1055/s-0039-3400965
Abstract: Puberty is a critical period of development regulated by genetic, nutritional, and environmental factors. The role of makorin ring finger protein 3 (MKRN3) in the regulation of pubertal timing was revealed when loss-of-function mutations were… read more here.
Keywords: mkrn3; endocrine functions; initiation endocrine; evolutionary conservation ... See more keywords
ASES: Visualising evolutionary conservation of alternative splicing in proteins.
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac105
Abstract: SUMMARY ASES is a versatile tool for assessing the impact of alternative splicing, initiation and termination of transcription on protein diversity in evolution. It identifies exon and transcript orthogroups from a set of input genes/species… read more here.
Keywords: evolutionary conservation; conservation; visualising evolutionary; alternative splicing ... See more keywords
Evolutionary Conservation and Transcriptome Analyses Attribute Perenniality and Flowering to Day-Length Responsive Genes in Bulbous Barley (Hordeum bulbosum)
Sign Up to like & getrecommendations! Published in 2022 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evac168
Abstract: Abstract Rapid population growth and dramatic climatic turnovers are challenging global crop production. These challenges are spurring plant breeders to enhance adaptation and sustainability of major crops. One intriguing approach is to turn annual systems… read more here.
Keywords: evolutionary conservation; barley; hordeum bulbosum; perenniality ... See more keywords
Utilizing evolutionary conservation to detect deleterious mutations and improve genomic prediction in cassava
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.1041925
Abstract: Cassava (Manihot esculenta) is an annual root crop which provides the major source of calories for over half a billion people around the world. Since its domestication ∼10,000 years ago, cassava has been largely clonally… read more here.
Keywords: evolutionary conservation; genomic prediction; deleterious mutations; prediction ... See more keywords
Evolutionary conservation of nested MIR159 structural microRNA genes and their promoter characterization in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.948751
Abstract: MicroRNAs (miRNAs) are endogenous small RNAs, that are vital for gene expression regulation in eukaryotes. Whenever a pri-miRNA precursor includes another miRNA precursor, and both of these precursors may generate independent, non-overlapping mature miRNAs, we… read more here.
Keywords: promoter; evolutionary conservation; mir159 structural; nested mir159 ... See more keywords