SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06114-3
Abstract: Wntless transports Wnt morphogens to the cell surface and is required for Wnt secretion and morphogenic gradients formation. Recycling of endocytosed Wntless requires the sorting nexin-3 (SNX3)-retromer-dependent endosome-to-Golgi transport pathway. Here we demonstrate the essential… read more here.
Keywords: wntless; evolutionary conserved; wnt secretion; snx3 retromer ... See more keywords
Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation
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DOI: 10.1038/s41467-020-16103-0
Abstract: Cells rely on a diverse repertoire of genes for maintaining homeostasis, but the transcriptional networks underlying their expression remain poorly understood. The MOF acetyltransferase-containing Non-Specific Lethal (NSL) complex is a broad transcription regulator. It is… read more here.
Keywords: histone acetylation; transcription; evolutionary conserved; brd4 ... See more keywords
G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer’s disease
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DOI: 10.1038/s41467-021-22129-9
Abstract: DNA sequences containing consecutive guanines organized in 4-interspaced tandem repeats can form stable single-stranded secondary structures, called G-quadruplexes (G4). Herein, we report that the Polycomb group protein BMI1 is enriched at heterochromatin regions containing putative… read more here.
Keywords: evolutionary conserved; alzheimer disease; neuronal gene; gene expression ... See more keywords
An Evolutionary Conserved Signaling Network Between Mouse and Human Underlies the Differential Osteoskeletal Potential of Frontal and Parietal Calvarial Bones
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.747091
Abstract: The mammalian calvarial vault is an ancient and highly conserved structure among species, however, the mechanisms governing osteogenesis of the calvarial vault and how they might be conserved across mammalian species remain unclear. The aim… read more here.
Keywords: calvarial vault; evolutionary conserved; mouse human; frontal parietal ... See more keywords
Functionally Validating Evolutionary Conserved Risk Genes for Parkinson’s Disease in Drosophila melanogaster
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DOI: 10.3390/insects14020168
Abstract: Simple Summary The neurodegenerative disorder Parkinson’s disease (PD) has a multifactorial etiology, and recent large-scale genetic studies have identified more than one hundred regions in the human genome that display statistical association with the risk… read more here.
Keywords: disease; parkinson disease; gene expression; evolutionary conserved ... See more keywords
PNPLA6/NTE, an Evolutionary Conserved Phospholipase Linked to a Group of Complex Human Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12040284
Abstract: Patatin-like phospholipase domain-containing protein 6 (PNPLA6), originally called Neuropathy Target Esterase (NTE), belongs to a family of hydrolases with at least eight members in mammals. PNPLA6/NTE was first identified as a key factor in Organophosphate-induced… read more here.
Keywords: phospholipase; pnpla6 nte; nte evolutionary; evolutionary conserved ... See more keywords