Evolutionary coupling analysis guides identification of mistrafficking-sensitive variants in cardiac K+ channels: Validation with hERG
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DOI: 10.3389/fphar.2022.1010119
Abstract: Loss of function (LOF) mutations of voltage sensitive K+ channel proteins hERG (Kv11.1) and KCNQ1 (Kv7.1) account for the majority of instances of congenital Long QT Syndrome (cLQTS) with the dominant molecular phenotype being a… read more here.
Keywords: analysis guides; coupling analysis; analysis; evolutionary coupling ... See more keywords