Chasing long‐range evolutionary couplings in the AlphaFold era
Sign Up to like & getrecommendations! Published in 2023 at "Biopolymers"
DOI: 10.1002/bip.23530
Abstract: Coevolution between protein residues is normally interpreted as direct contact. However, the evolutionary record of a protein sequence contains rich information that may include long‐range functional couplings, couplings that report on homo‐oligomeric states or even… read more here.
Keywords: alphafold era; chasing long; long range; range evolutionary ... See more keywords
Evolutionary couplings of amino acid residues reveal structure and function of bacterial signaling proteins
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Microbiology"
DOI: 10.1111/mmi.14282
Abstract: The genomic era along with major advances in high‐throughput sequencing technology has led to a rapid expansion of the genomic and consequently the protein sequence space. Bacterial extracytoplasmic function sigma factors have emerged as an… read more here.
Keywords: protein; couplings amino; signaling proteins; structure ... See more keywords
Evolutionary Couplings and Molecular Dynamic Simulations Highlight Details of GPCRs Heterodimers’ Interfaces
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28041838
Abstract: A growing body of evidence suggests that only a few amino acids (“hot-spots”) at the interface contribute most of the binding energy in transient protein-protein interactions. However, experimental protocols to identify these hot-spots are highly… read more here.
Keywords: highlight details; hot spots; methodology; molecular dynamic ... See more keywords