Bridging the gap between the evolutionary dynamics and the molecular mechanisms of meiosis: A model based exploration of the PRDM9 intra-genomic Red Queen
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Genetics"
DOI: 10.1101/2023.03.08.531712
Abstract: Molecular dissection of meiotic recombination in mammals, combined with population-genetic and comparative studies, have revealed a complex evolutionary dynamic characterized by short-lived recombination hotspots. Hotspots are chromosome positions containing DNA sequences where the protein PRDM9… read more here.
Keywords: recombination; evolutionary dynamic; meiosis; prdm9 ... See more keywords
New insights into the evolutionary dynamic and lineage divergence of gasdermin E in metazoa
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.952015
Abstract: Gasdermin (GSDM) is a family of pore-forming proteins that induce pyroptosis. To date, the origin and evolution of GSDM in Metazoa remain elusive. Here, we found that GSDM emerged early in Placozoa but is absent… read more here.
Keywords: gasdermin; insights evolutionary; recognition motif; caspase recognition ... See more keywords