iPhos‐PseEvo: Identifying Human Phosphorylated Proteins by Incorporating Evolutionary Information into General PseAAC via Grey System Theory
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Informatics"
DOI: 10.1002/minf.201600010
Abstract: Protein phosphorylation plays a critical role in human body by altering the structural conformation of a protein, causing it to become activated/deactivated, or functional modification. Given an uncharacterized protein sequence, can we predict whether it… read more here.
Keywords: pseevo; system; information general; evolutionary information ... See more keywords
Multi‐iPPseEvo: A Multi‐label Classifier for Identifying Human Phosphorylated Proteins by Incorporating Evolutionary Information into Chou′s General PseAAC via Grey System Theory
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Informatics"
DOI: 10.1002/minf.201600085
Abstract: Predicting phosphorylation protein is a challenging problem, particularly when query proteins have multi‐label features meaning that they may be phosphorylated at two or more different type amino acids. In fact, human protein usually be phosphorylated… read more here.
Keywords: multi; system; multi label; multi ippseevo ... See more keywords
How is structural divergence related to evolutionary information?
Sign Up to like & getrecommendations! Published in 2018 at "Molecular phylogenetics and evolution"
DOI: 10.1016/j.ympev.2018.06.033
Abstract: The analysis of evolutionary information in a protein family, such as conservation and covariation, is often linked to its structural information. Multiple sequence alignments of distant homologous sequences are used to measure evolutionary variables. Although… read more here.
Keywords: structural information; information; structural divergence; evolutionary information ... See more keywords
CLIP: accurate prediction of disordered linear interacting peptides from protein sequences using co-evolutionary information
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac502
Abstract: One of key features of intrinsically disordered regions (IDRs) is facilitation of protein-protein and protein-nucleic acids interactions. These disordered binding regions include molecular recognition features (MoRFs), short linear motifs (SLiMs) and longer binding domains. Vast… read more here.
Keywords: disordered protein; evolutionary information; binding regions; protein binding ... See more keywords
Use Chou's 5-Step Rule to Predict DNA-Binding Proteins with Evolutionary Information
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DOI: 10.1155/2020/6984045
Abstract: The knowledge of DNA-binding proteins would help to understand the functions of proteins better in cellular biological processes. Research on the prediction of DNA-binding proteins can promote the research of drug proteins and computer acidified… read more here.
Keywords: chou step; evolutionary information; binding proteins; dna binding ... See more keywords
Inferring repeat-protein energetics from evolutionary information
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1005584
Abstract: Natural protein sequences contain a record of their history. A common constraint in a given protein family is the ability to fold to specific structures, and it has been shown possible to infer the main… read more here.
Keywords: protein; inferring repeat; energetics evolutionary; evolutionary information ... See more keywords
RNA structure prediction using positive and negative evolutionary information
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1008387
Abstract: Knowing the structure of conserved structural RNAs is important to elucidate their function and mechanism of action. However, predicting a conserved RNA structure remains unreliable, even when using a combination of thermodynamic stability and evolutionary… read more here.
Keywords: negative evolutionary; covariation; evolutionary information; structure ... See more keywords
Genome-wide scan for potential CD4+ T-cell vaccine candidates in Candida auris by exploiting reverse vaccinology and evolutionary information
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.1008527
Abstract: Candida auris is a globally emerging fungal pathogen responsible for causing nosocomial outbreaks in healthcare associated settings. It is known to cause infection in all age groups and exhibits multi-drug resistance with high potential for… read more here.
Keywords: cell; reverse vaccinology; candida auris; vaccine candidates ... See more keywords