Evolutionary rate heterogeneity between multi- and single-interface hubs across human housekeeping and tissue-specific protein interaction network: Insights from proteins' and its partners' properties.
Sign Up to like & getrecommendations! Published in 2018 at "Genomics"
DOI: 10.1016/j.ygeno.2017.11.006
Abstract: Integrating gene expression into protein-protein interaction network (PPIN) leads to the construction of tissue-specific (TS) and housekeeping (HK) sub-networks, with distinctive TS- and HK-hubs. All such hub proteins are divided into multi-interface (MI) hubs and… read more here.
Keywords: protein; partners properties; tissue; interface hubs ... See more keywords
Drivers of avian genomic change revealed by evolutionary rate decomposition
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DOI: 10.1038/s41586-025-08777-7
Abstract: Modern birds have diversified into a striking array of forms, behaviours and ecological roles. Analyses of molecular evolutionary rates can reveal the links between genomic and phenotypic change1, 2, 3–4, but disentangling the drivers of… read more here.
Keywords: evolutionary rates; evolutionary rate; rate; rate variation ... See more keywords
Evolutionary rate covariation is a reliable predictor of co-functional interactions but not necessarily physical interactions
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DOI: 10.1101/2023.10.18.562970
Abstract: Co-functional proteins tend to have rates of evolution that covary over time. This correlation between evolutionary rates can be measured over the branches of a phylogenetic tree through methods such as evolutionary rate covariation (ERC),… read more here.
Keywords: rate covariation; physical interactions; functional interactions; evolutionary rate ... See more keywords
Evolutionary rate and genetic load in an emblematic Mediterranean tree following an ancient and prolonged population collapse
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DOI: 10.1111/mec.15684
Abstract: Severe bottlenecks significantly diminish the amount of genetic diversity and the speed at which it accumulates (i.e., evolutionary rate). They further compromise the efficiency of natural selection to eliminate deleterious variants, which may reach fixation… read more here.
Keywords: diversity; evolutionary rate; load; population ... See more keywords
Molecular evolution of TRPC4 regulatory sequences supports a role in mammalian thermoregulatory adaptation
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DOI: 10.7717/peerj.19697
Abstract: Background Proteins encoded by the canonical transient receptor potential (Trpc) gene family form transmembrane channels involved in diverse signal-transduction pathways. Trpc4 has been shown necessary for the induction of nonshivering thermogenesis (NST) in mice, a… read more here.
Keywords: mammalian thermoregulatory; evolutionary rate; regulatory sequences; selection ... See more keywords