Repurposing Drugs Based on Evolutionary Relationships Between Targets of Approved Drugs and Proteins of Interest.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8955-3_3
Abstract: Drug repurposing has garnered much interest as an effective method for drug development among biopharmaceutical companies. The availability of information on complete sequences of genomes and their associated biological data, genotype-phenotype-disease relationships, and properties of… read more here.
Keywords: repurposing drugs; evolutionary relationships; drugs proteins; approved drugs ... See more keywords
Evolutionary relationships of Bresadolia (Basidiomycota, Polyporales) based on molecular and morphological evidence
Sign Up to like & getrecommendations! Published in 2018 at "Mycological Progress"
DOI: 10.1007/s11557-018-1416-3
Abstract: In the last decades, several phylogenetic studies have shown that Polyporus is polyphyletic; accordingly, several genera have been newly described or reinstated. Nevertheless, the phylogenetic position of many species in the genus remains highly contentious,… read more here.
Keywords: evolutionary relationships; bresadolia basidiomycota; relationships bresadolia; based molecular ... See more keywords
Evolutionary relationships between the transcriptional repressors of the polyhydroxyalkanoate reserve storage system in prokaryotes: conserved but phylogenetically heterogeneous.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.144397
Abstract: Bacteria and archaea accumulate cytoplasmic polyhydroxyalkanoate (PHA) granules under nutrient-limited conditions with excess carbon. The transcriptional regulatory (TR) proteins found on the surface of PHA granules act as repressors as well as activators for the… read more here.
Keywords: evolutionary relationships; storage system; reserve storage;
Evolutionary relationships and climatic niche evolution in the genus Handleyomys (Sigmodontinae: Oryzomyini).
Sign Up to like & getrecommendations! Published in 2018 at "Molecular phylogenetics and evolution"
DOI: 10.1016/j.ympev.2018.06.018
Abstract: Mesoamerica is considered a biodiversity hot spot with levels of endemism and species diversity likely underestimated. Unfortunately, the region continues to experience some of the highest deforestation rates in the world. For mammals, the evolutionary… read more here.
Keywords: evolutionary relationships; niche evolution; handleyomys; genus handleyomys ... See more keywords
Understanding the co-evolutionary relationships between Indigenous cultures and non-native species can inform more effective approaches to conservation: the example of pigs (pua
Sign Up to like & getrecommendations! Published in 2021 at "Pacific Conservation Biology"
DOI: 10.1071/pc20086
Abstract: Indigenous resource management (IRM) is dynamic and ever evolving, in part because it is based on co-evolutionary relationships between Indigenous cultures and the biodiversity around them. Forms of conservation imposed on Indigenous people and places… read more here.
Keywords: evolutionary relationships; indigenous cultures; relationships indigenous; conservation ... See more keywords
Evolutionary relationships among Massospora spp. (Entomophthorales), obligate pathogens of cicadas
Sign Up to like & getrecommendations! Published in 2020 at "Mycologia"
DOI: 10.1080/00275514.2020.1742033
Abstract: ABSTRACT The fungal genus Massospora (Zoopagomycota: Entomophthorales) includes more than a dozen obligate, sexually transmissible pathogenic species that infect cicadas (Hemiptera) worldwide. At least two species are known to produce psychoactive compounds during infection, which… read more here.
Keywords: evolutionary relationships; spp entomophthorales; relationships among; among massospora ... See more keywords
Structural Phylogenetics with Confidence
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msaa100
Abstract: Abstract For evaluating the deepest evolutionary relationships among proteins, sequence similarity is too low for application of sequence-based homology search or phylogenetic methods. In such cases, comparison of protein structures, which are often better conserved… read more here.
Keywords: structural phylogenetics; evolutionary relationships; protein; confidence ... See more keywords
Exploring Evolutionary Relationships Across the Genome Using Topology Weighting
Sign Up to like & getrecommendations! Published in 2017 at "Genetics"
DOI: 10.1534/genetics.116.194720
Abstract: We introduce the concept of topology weighting, a method for quantifying relationships between taxa that are not necessarily monophyletic, and visualizing how these relationships change across the genome. A given set of taxa can be… read more here.
Keywords: evolutionary relationships; exploring evolutionary; across genome; topology ... See more keywords
Comparative chloroplast genome analyses of 23 species in Swertia L. (Gentianaceae) with implications for its phylogeny
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.895146
Abstract: Swertia L. is a large genus in the family Gentianaceae. Different chloroplast gene segments have been used to study systematic evolutionary relationships between species of Swertia L. However, as gene fragment–based phylogenies lack sufficient resolution,… read more here.
Keywords: chloroplast; evolutionary relationships; swertia; swertia species ... See more keywords
Pervasive Phylogenomic Incongruence Underlies Evolutionary Relationships in Eyebrights (Euphrasia, Orobanchaceae)
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.869583
Abstract: Disentangling the phylogenetic relationships of taxonomically complex plant groups is often mired by challenges associated with recent speciation, hybridization, complex mating systems, and polyploidy. Here, we perform a phylogenomic analysis of eyebrights (Euphrasia), a group… read more here.
Keywords: evolutionary relationships; incongruence underlies; underlies evolutionary; eyebrights euphrasia ... See more keywords
Evolutionary Relationships and Range Evolution of Greenhood Orchids (Subtribe Pterostylidinae): Insights From Plastid Phylogenomics
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.912089
Abstract: Australia harbours a rich and highly endemic orchid flora with over 90% of native species found nowhere else. However, little is known about the assembly and evolution of Australia’s orchid flora. Here, we used a… read more here.
Keywords: pterostylidinae; orchid flora; eastern australia; evolutionary relationships ... See more keywords