Repurposing Drugs Based on Evolutionary Relationships Between Targets of Approved Drugs and Proteins of Interest.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8955-3_3
Abstract: Drug repurposing has garnered much interest as an effective method for drug development among biopharmaceutical companies. The availability of information on complete sequences of genomes and their associated biological data, genotype-phenotype-disease relationships, and properties of… read more here.
Keywords: repurposing drugs; evolutionary relationships; drugs proteins; approved drugs ... See more keywords
Evolutionary relationships of Bresadolia (Basidiomycota, Polyporales) based on molecular and morphological evidence
Sign Up to like & getrecommendations! Published in 2018 at "Mycological Progress"
DOI: 10.1007/s11557-018-1416-3
Abstract: In the last decades, several phylogenetic studies have shown that Polyporus is polyphyletic; accordingly, several genera have been newly described or reinstated. Nevertheless, the phylogenetic position of many species in the genus remains highly contentious,… read more here.
Keywords: evolutionary relationships; bresadolia basidiomycota; relationships bresadolia; based molecular ... See more keywords
Evolutionary relationships between the transcriptional repressors of the polyhydroxyalkanoate reserve storage system in prokaryotes: conserved but phylogenetically heterogeneous.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.144397
Abstract: Bacteria and archaea accumulate cytoplasmic polyhydroxyalkanoate (PHA) granules under nutrient-limited conditions with excess carbon. The transcriptional regulatory (TR) proteins found on the surface of PHA granules act as repressors as well as activators for the… read more here.
Keywords: evolutionary relationships; storage system; reserve storage;
Evolutionary relationships and climatic niche evolution in the genus Handleyomys (Sigmodontinae: Oryzomyini).
Sign Up to like & getrecommendations! Published in 2018 at "Molecular phylogenetics and evolution"
DOI: 10.1016/j.ympev.2018.06.018
Abstract: Mesoamerica is considered a biodiversity hot spot with levels of endemism and species diversity likely underestimated. Unfortunately, the region continues to experience some of the highest deforestation rates in the world. For mammals, the evolutionary… read more here.
Keywords: evolutionary relationships; niche evolution; handleyomys; genus handleyomys ... See more keywords
New comatulid crinoids from the Early Cretaceous Glen Rose Formation (Texas, USA): paleobiology and evolutionary relationships of an endemic, ephemeral giant
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Paleontology"
DOI: 10.1017/jpa.2024.37
Abstract: Abstract The free-living, stalkless comatulids make up the bulk of living crinoid diversity and are the only crinoids remaining in shallow water, but compared to the stalked crinoids their fossil record is fragmentary and understudied,… read more here.
Keywords: glen rose; evolutionary relationships; paleobiology; rose formation ... See more keywords
Chromosome fusions shaped karyotype evolution and evolutionary relationships in the model family Brassicaceae
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-59640-2
Abstract: The ancestral crucifer karyotype and 22 conserved genomic blocks (CGBs) facilitate phylogenomic analyses in the Brassicaceae. Chromosomal rearrangements reshuffled CGBs of ancestral chromosomes during karyotype evolution. Here, we identify eight protochromosomes representing the common ancestral… read more here.
Keywords: chromosome fusions; fusions shaped; evolutionary relationships; karyotype evolution ... See more keywords
Clustering analysis for the evolutionary relationships of SARS-CoV-2 strains
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-57001-5
Abstract: To explore the differences and relationships between the available SARS-CoV-2 strains and predict the potential evolutionary direction of these strains, we employ the hierarchical clustering analysis to investigate the evolutionary relationships between the SARS-CoV-2 strains… read more here.
Keywords: sars cov; cov strains; clustering analysis; evolutionary relationships ... See more keywords
Nine complete chloroplast genomes of the Camellia genus provide insights into evolutionary relationships and species differentiation
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-87764-4
Abstract: The genus Camellia, known for species such as Camellia japonica, is of significant agricultural and ecological importance. However, the genetic diversity and evolutionary relationships among Camellia species remain insufficiently explored. In this study, we successfully… read more here.
Keywords: complete chloroplast; species differentiation; chloroplast genomes; xiameng ... See more keywords
Understanding the co-evolutionary relationships between Indigenous cultures and non-native species can inform more effective approaches to conservation: the example of pigs (pua
Sign Up to like & getrecommendations! Published in 2021 at "Pacific Conservation Biology"
DOI: 10.1071/pc20086
Abstract: Indigenous resource management (IRM) is dynamic and ever evolving, in part because it is based on co-evolutionary relationships between Indigenous cultures and the biodiversity around them. Forms of conservation imposed on Indigenous people and places… read more here.
Keywords: evolutionary relationships; indigenous cultures; relationships indigenous; conservation ... See more keywords
Evolutionary relationships among Massospora spp. (Entomophthorales), obligate pathogens of cicadas
Sign Up to like & getrecommendations! Published in 2020 at "Mycologia"
DOI: 10.1080/00275514.2020.1742033
Abstract: ABSTRACT The fungal genus Massospora (Zoopagomycota: Entomophthorales) includes more than a dozen obligate, sexually transmissible pathogenic species that infect cicadas (Hemiptera) worldwide. At least two species are known to produce psychoactive compounds during infection, which… read more here.
Keywords: evolutionary relationships; spp entomophthorales; relationships among; among massospora ... See more keywords
Reconstructing tumor clonal heterogeneity and evolutionary relationships based on tumor DNA sequencing data
Sign Up to like & getrecommendations! Published in 2024 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbae516
Abstract: Abstract The heterogeneity of tumor clones drives the selection and evolution of distinct tumor cell populations, resulting in an intricate and dynamic tumor evolution process. While tumor bulk DNA sequencing helps elucidate intratumor heterogeneity, challenges… read more here.
Keywords: evolution; evolutionary relationships; tumor; clonal heterogeneity ... See more keywords