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Published in 2018 at "Engineering Structures"
DOI: 10.1016/j.engstruct.2018.02.032
Abstract: Abstract The Smoothing Evolutionary Structural Optimization (SESO) technique was extended to solve 2D elastic problems with constraint of displacements or natural frequencies. At the end of each finite element analysis, a scalar representing the sensitivity…
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Keywords:
smoothing evolutionary;
optimization;
structural optimization;
optimization structures ... See more keywords
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Published in 2017 at "Finite Elements in Analysis and Design"
DOI: 10.1016/j.finel.2017.03.005
Abstract: Abstract This paper proposes the introduction of a connectivity constraint in the Bi-directional Evolutionary Structural Optimisation (BESO) method, which avoids the possibility of arriving at highly non-optimal local optima. By developing a constraint that looks…
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Keywords:
directional evolutionary;
connectivity constraint;
optimisation;
structural optimisation ... See more keywords
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Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00404
Abstract: The U.S. FDA approval of PAXLOVID, a combination therapy of nirmatrelvir and ritonavir has significantly boosted our morale in fighting the COVID-19 pandemic. Nirmatrelvir is an inhibitor of the main protease (MPro) of SARS-CoV-2. Since…
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Keywords:
structural insights;
nirmatrelvir;
evasion nirmatrelvir;
sars cov ... See more keywords