What determines the evolutionary trajectories of wild plant species? Approaches to the study of quantitative fitness-related traits.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of botany"
DOI: 10.1002/ajb2.16097
Abstract: Wild plant species provide excellent examples of qualitative traits that evolve in response to environmental challenges (e.g., flower color, heavy metal tolerance, cyanogenesis, and male sterility). In addition to such discrete characters, a dazzling array… read more here.
Keywords: evolutionary trajectories; wild plant; botany; plant species ... See more keywords
Divergent evolutionary trajectories in transplanted tumor models
Sign Up to like & getrecommendations! Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3983
Abstract: Human-derived tumor models are becoming popular in the context of personalized medicine, but a new study shows that these models could be less representative of primary tumors than previously thought, particularly when using late passages. read more here.
Keywords: trajectories transplanted; tumor models; evolutionary trajectories; transplanted tumor ... See more keywords
Unique evolutionary trajectories of breast cancers with distinct genomic and spatial heterogeneity
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-90170-1
Abstract: Breast cancers exhibit intratumoral heterogeneity associated with disease progression and therapeutic resistance. To define the sources and the extent of heterogeneity, we performed an in-depth analysis of the genomic architecture of three chemoradiation-naïve breast cancers… read more here.
Keywords: heterogeneity; unique evolutionary; evolutionary trajectories; breast cancers ... See more keywords
Gene evolutionary trajectories in Mycobacterium tuberculosis reveal temporal signs of selection.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2113600119
Abstract: SignificancePrevious attempts to identify the action of natural selection in the Mycobacterium tuberculosis complex (MTBC) were limited by sample size and averaging across time and lineages. We investigate changes in selective pressures across time for… read more here.
Keywords: gene evolutionary; selection; evolutionary trajectories; mycobacterium tuberculosis ... See more keywords
A tale of two copies: Evolutionary trajectories of moth pheromone receptors
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2221166120
Abstract: Significance Moths have served as historical models for animal communication studies. As their sex pheromone system is expected to be fine-tuned and under stabilizing selection, understanding its evolution has attracted interest for a long time.… read more here.
Keywords: evolutionary trajectories; tale two; copies evolutionary; two copies ... See more keywords
Identification of conserved evolutionary trajectories in tumors.
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa453
Abstract: MOTIVATION As multi-region, time-series and single-cell sequencing data become more widely available; it is becoming clear that certain tumors share evolutionary characteristics with others. In the last few years, several computational methods have been developed… read more here.
Keywords: conserved evolutionary; evolutionary trajectories; conett; trajectories tumors ... See more keywords
Discovering significant evolutionary trajectories in cancer phylogenies.
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac467
Abstract: MOTIVATION Tumors are the result of a somatic evolutionary process leading to substantial intra-tumor heterogeneity. Single-cell and multi-region sequencing enable the detailed characterization of the clonal architecture of tumors and have highlighted its extensive diversity… read more here.
Keywords: discovering significant; evolutionary trajectories; significant evolutionary; cancer phylogenies ... See more keywords
Identification of evolutionary trajectories shared across human betacoronaviruses.
Sign Up to like & getrecommendations! Published in 2023 at "Genome biology and evolution"
DOI: 10.1093/gbe/evad076
Abstract: Comparing the evolution of distantly related viruses can provide insights into common adaptive processes related to shared ecological niches. Phylogenetic approaches, coupled with other molecular evolution tools, can help identify mutations informative on adaptation, whilst… read more here.
Keywords: evolutionary trajectories; shared across; identification evolutionary; trajectories shared ... See more keywords
Evolutionary Trajectories are Contingent on Mitonuclear Interactions
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msad061
Abstract: Critical mitochondrial functions, including cellular respiration, rely on frequently interacting components expressed from both the mitochondrial and nuclear genomes. The fitness of eukaryotic organisms depends on a tight collaboration between both genomes. In the face… read more here.
Keywords: evolutionary trajectories; mitonuclear interactions; trajectories contingent; genome ... See more keywords
Evolutionary Trajectories of New Duplicated and Putative De Novo Genes
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msad098
Abstract: Abstract The formation of new genes during evolution is an important motor of functional innovation, but the rate at which new genes originate and the likelihood that they persist over longer evolutionary periods are still… read more here.
Keywords: evolutionary trajectories; putative novo; trajectories new; new duplicated ... See more keywords
Phylogenomics of SAR116 Clade Reveals Two Subclades with Different Evolutionary Trajectories and an Important Role in the Ocean Sulfur Cycle
Sign Up to like & getrecommendations! Published in 2021 at "mSystems"
DOI: 10.1128/msystems.00944-21
Abstract: The SAR116 clade of Alphaproteobacteria is a ubiquitous group of heterotrophic bacteria inhabiting the surface of the ocean, but the information about their ecology and population genomic diversity is scarce due to the difficulty of… read more here.
Keywords: study; two subclades; ecology; sar116 clade ... See more keywords