Ferritins in Chordata: Potential evolutionary trajectory marked by discrete selective pressures
Sign Up to like & getrecommendations! Published in 2020 at "BioEssays"
DOI: 10.1002/bies.202000207
Abstract: Ferritins (FTs) are iron storage proteins that are involved in managing iron‐oxygen balance. In our work, we present a hypothesis on the putative effect of geological changes that have affected the evolution and radiation of… read more here.
Keywords: ferritins chordata; chordata potential; potential evolutionary; marked discrete ... See more keywords
From Structure to Application: The Evolutionary Trajectory of Spherical Nucleic Acids.
Sign Up to like & getrecommendations! Published in 2024 at "Small"
DOI: 10.1002/smll.202310026
Abstract: Since the proposal of the concept of spherical nucleic acids (SNAs) in 1996, numerous studies have focused on this topic and have achieved great advances. As a new delivery system for nucleic acids, SNAs have… read more here.
Keywords: spherical nucleic; structure application; application evolutionary; evolutionary trajectory ... See more keywords
Conserved Evolutionary Trajectory Can Be Perturbed to Prevent Resistance Evolution under Norfloxacin Pressure by Forcing Mycobacterium smegmatis on Alternate Evolutionary Paths.
Sign Up to like & getrecommendations! Published in 2024 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.3c00605
Abstract: Antibiotic resistance is a pressing health issue, with the emergence of resistance in bacteria outcompeting the discovery of novel drug candidates. While many studies have used Adaptive Laboratory Evolution (ALE) to understand the determinants of… read more here.
Keywords: resistance; mycobacterium smegmatis; drug; target ... See more keywords
Optimization of Enzyme Mechanism along the Evolutionary Trajectory of a Computationally Designed (Retro-)Aldolase.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b05796
Abstract: De novo biocatalysts have been successfully generated by computational design and subsequent experimental optimization. Here, we examined the evolutionary history of the computationally designed (retro-)aldolase RA95. The modest activity of the starting enzyme was previously… read more here.
Keywords: mechanism; designed retro; retro aldolase; computationally designed ... See more keywords
Evolutionary trajectory and characteristics of Mpox virus in 2023 based on a large-scale genomic surveillance in Shenzhen, China
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-51737-4
Abstract: The global epidemic of Mpox virus (MPXV) continues, and a local outbreak has occurred in Shenzhen city since June 2023. Herein, the evolutionary trajectory and characteristics of MPXV in 2023 were analyzed using 92 MPXV… read more here.
Keywords: trajectory characteristics; lineage; mpox virus; evolutionary trajectory ... See more keywords
The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac065
Abstract: Abstract The shelterin protein complex is required for telomere protection in various eukaryotic organisms. In mammals, the shelterin subunit TRF2 is specialized in preventing ATM activation at telomeres and chromosome end fusion in somatic cells.… read more here.
Keywords: trf2 zebrafish; telomeric evolutionary; trf2; non telomeric ... See more keywords
Increased Expression of Efflux Pump norA Drives the Rapid Evolutionary Trajectory from Tolerance to Resistance against Ciprofloxacin in Staphylococcus aureus
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00594-22
Abstract: The intensively intermittent use of antibiotics promotes the rapid evolution of tolerance, which may lead to resistance acquisition in the following evolutionary trajectory. In addition to directly exporting antibiotics as an instant resistance strategy, efflux… read more here.
Keywords: tolerance resistance; ciprofloxacin; resistance; tolerance ... See more keywords
Identification of PilD mutants reveals the iterative social evolution in Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2025 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.00915-25
Abstract: ABSTRACT Bacterial pathogenicity is influenced by the genetic mutations that arise within the population, among which quorum-sensing (QS) is one of the key targets. Recent studies have reported that mutations in the global transcriptional regulator… read more here.
Keywords: evolution; pathogenicity; evolutionary trajectory; iterative social ... See more keywords
Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe
Sign Up to like & getrecommendations! Published in 2021 at "Emerging Infectious Diseases"
DOI: 10.3201/eid2706.203096
Abstract: In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016–2018. Most E30… read more here.
Keywords: recombinant forms; trajectory emerging; epidemiology evolutionary; epidemiology ... See more keywords
Evolutionary trajectory of leukemic clones and its clinical implications
Sign Up to like & getrecommendations! Published in 2019 at "Haematologica"
DOI: 10.3324/haematol.2018.195289
Abstract: The ontogeny of acute myeloid leukemia is a multistep process. It is driven both by features of the malignant clone itself as well as by environmental pressures, making it a unique process in each individual.… read more here.
Keywords: clinical implications; evolutionary trajectory; clones clinical; trajectory leukemic ... See more keywords
Evolutionary Trajectory for the Emergence of Novel Coronavirus SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "Pathogens"
DOI: 10.3390/pathogens9030240
Abstract: Over the last two decades, the world experienced three outbreaks of coronaviruses with elevated morbidity rates. Currently, the global community is facing emerging virus SARS-CoV-2 belonging to Betacoronavirus, which appears to be more transmissible but… read more here.
Keywords: novel coronavirus; trajectory emergence; emergence novel; sars cov ... See more keywords