Tumor-reactive antibodies evolve from non-binding and autoreactive precursors
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DOI: 10.1016/j.cell.2022.02.012
Abstract: The tumor microenvironment hosts antibody-secreting cells (ASCs) associated with a favorable prognosis in several types of cancer. Patient-derived antibodies have diagnostic and therapeutic potential; yet, it remains unclear how antibodies gain autoreactivity and target tumors.… read more here.
Keywords: tumor; evolve non; reactive antibodies; tumor reactive ... See more keywords