Restoration of fitness lost due to dysregulation of the pyruvate dehydrogenase complex is triggered by ribosomal binding site modifications
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108961
Abstract: SUMMARY Pyruvate dehydrogenase complex (PDC) functions as the main determinant of the respiro-fermentative balance because it converts pyruvate to acetyl-coenzyme A (CoA), which then enters the TCA (tricarboxylic acid cycle). PDC is repressed by the… read more here.
Keywords: pdc; dehydrogenase complex; evolved strains; pyruvate dehydrogenase ... See more keywords
Whole-genome sequences from wild-type and laboratory-evolved strains define the alleleome and establish its hallmarks
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2218835120
Abstract: Significance The wide range of behaviors exhibited by Escherichia coli isolated from diverse environments is expected to be reflected in the sequence variation of its genome. Large-scale multi-strain assessment of the E. coli genome finds… read more here.
Keywords: type laboratory; laboratory evolved; whole genome; evolved strains ... See more keywords