Designer Extracellular Vesicles Modulate Pro‐Neuronal Cell Responses and Improve Intracranial Retention
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202100805
Abstract: Gene/oligonucleotide therapies have emerged as a promising strategy for the treatment of different neurological conditions. However, current methodologies for the delivery of neurogenic/neurotrophic cargo to brain and nerve tissue are fraught with caveats, including reliance… read more here.
Keywords: evs; pro neuronal; delivery; extracellular vesicles ... See more keywords
Brain Microenvironment Responsive and Pro‐Angiogenic Extracellular Vesicle‐Hydrogel for Promoting Neurobehavioral Recovery in Type 2 Diabetic Mice After Stroke
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201150
Abstract: Stroke patients with diabetes have worse neurological outcomes than non‐diabetic stroke patients, and treatments beneficial for non‐diabetic stroke patients are not necessarily effective for diabetic stroke patients. While stem cell‐derived extracellular vesicles (EVs) show potential… read more here.
Keywords: hydrogel; brain; evs; diabetic stroke ... See more keywords
Proteome profiling of salivary small extracellular vesicles in glioblastoma patients.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34888
Abstract: BACKGROUND Extracellular vesicles (EVs) play a critical role in intercellular communication under physiological and pathological conditions, including cancer. EVs cargo reflects their cell of origin, suggesting their utility as biomarkers. EVs are detected in several… read more here.
Keywords: salivary small; extracellular vesicles; saliva samples; evs ... See more keywords
High Purity Isolation and Sensitive Quantification of Extracellular Vesicles Using Affinity to TIM4
Sign Up to like & getrecommendations! Published in 2017 at "Current Protocols in Cell Biology"
DOI: 10.1002/cpcb.32
Abstract: Almost all types of cells secrete extracellular vesicles (EVs), including exosomes and microvesicles. EVs carry various proteins, lipids, mRNAs, and microRNAs, and may participate in many aspects of physiological and pathophysiological processes. Various studies are… read more here.
Keywords: extracellular vesicles; affinity; sensitive quantification; evs ... See more keywords
Characterization of Extracellular Vesicles in Osteoporotic Patients Compared to Osteopenic and Healthy Controls
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4688
Abstract: Extracellular vesicles (EVs) are mediators of a range of pathological conditions. However, their role in bone loss disease has not been well understood. In this study we characterized plasma EVs of 54 osteoporotic (OP) postmenopausal… read more here.
Keywords: extracellular vesicles; bone; healthy controls; rankl ... See more keywords
Adipose‐derived mesenchymal stem cells reduce autophagy in stroke mice by extracellular vesicle transfer of miR‐25
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12024
Abstract: Abstract Grafted mesenchymal stem cells (MSCs) yield neuroprotection in preclinical stroke models by secreting extracellular vesicles (EVs). The neuroprotective cargo of EVs, however, has not yet been identified. To investigate such cargo and its underlying… read more here.
Keywords: mir; evs; admsc evs; stem cells ... See more keywords
First‐in‐human intracochlear application of human stromal cell‐derived extracellular vesicles
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12094
Abstract: Abstract Extracellular vesicles (EVs) derived from the secretome of human mesenchymal stromal cells (MSC) contain numerous factors that are known to exert anti‐inflammatory effects. MSC‐EVs may serve as promising cell‐based therapeutics for the inner ear… read more here.
Keywords: extracellular vesicles; intracochlear application; msc evs; evs ... See more keywords
Extracellular Vesicle Capture by AnTibody of CHoice and Enzymatic Release (EV‐CATCHER): A customizable purification assay designed for small‐RNA biomarker identification and evaluation of circulating small‐EVs
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12110
Abstract: Abstract Circulating nucleic acids, encapsulated within small extracellular vesicles (EVs), provide a remote cellular snapshot of biomarkers derived from diseased tissues, however selective isolation is critical. Current laboratory‐based purification techniques rely on the physical properties… read more here.
Keywords: small rna; evs; purification assay; small evs ... See more keywords
TPI1‐reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12135
Abstract: Abstract Rab GTPases are major mediators that ensure the proper spatiotemporal regulation of intracellular trafficking. Functional impairment and altered expression of Rab proteins have been revealed in various human cancers. There is an emerging evidence… read more here.
Keywords: extracellular vesicles; rab; hcc; aerobic glycolysis ... See more keywords
Cell trafficking and regulation of osteoblastogenesis by extracellular vesicle associated bone morphogenetic protein 2.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of extracellular vesicles"
DOI: 10.1002/jev2.12155
Abstract: Extracellular vesicles (EVs) are characterized by complex cargo composition and carry a wide array of signalling cargo, including growth factors (GFs). Beyond surface-associated GFs, it is unclear if EV intralumenal growth factors are biologically active.… read more here.
Keywords: cell trafficking; bmp2; evs; osteoblastogenesis ... See more keywords
Lipid‐based strategies used to identify extracellular vesicles in flow cytometry can be confounded by lipoproteins: Evaluations of annexin V, lactadherin, and detergent lysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12200
Abstract: Abstract Flow cytometry (FCM) is a popular method used in characterisation of extracellular vesicles (EVs). Circulating EVs are often identified by FCM by exploiting the lipid nature of EVs by staining with Annexin V (Anx5)… read more here.
Keywords: extracellular vesicles; lysis; flow cytometry; evs ... See more keywords