SPOP and OTUD7A Control EWS–FLI1 Protein Stability to Govern Ewing Sarcoma Growth
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Science"
DOI: 10.1002/advs.202004846
Abstract: Abstract Chromosomal translocation results in development of an Ewing sarcoma breakpoint region 1‐Friend leukemia integration 1 (EWS–FLI1) fusion oncogene in the majority of Ewing sarcoma. The persistent dependence of the tumor for this oncoprotein points… read more here.
Keywords: ews fli1; sarcoma growth; fli1 protein; ewing sarcoma ... See more keywords
The clinical characteristics, novel predictive tool, and risk classification system for primary Ewing sarcoma patients that underwent chemotherapy: A large population‐based retrospective cohort study
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5379
Abstract: This study aims to determine the independent prognostic predictors of cancer‐specific survival (CSS) in patients with primary Ewing sarcoma (ES) that underwent chemotherapy and create a novel prognostic nomogram and risk stratification system. read more here.
Keywords: system; underwent chemotherapy; ewing sarcoma; primary ewing ... See more keywords
Long‐term follow‐up results of pediatric and adolescent patients with localized Ewing sarcoma treated based on stratified modalities
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DOI: 10.1002/cam4.5703
Abstract: Compared with other pediatric tumors, little advances were achieved in studies on the stratified treatment in localized Ewing sarcoma. Most pediatric oncology groups treated Ewing sarcoma according to whether there was an existing metastasis, without… read more here.
Keywords: long term; sarcoma; ewing sarcoma; localized ewing ... See more keywords
Second malignancies in Ewing sarcoma survivors
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DOI: 10.1002/cncr.30922
Abstract: We read the article by Marina et al on the long-term follow-up of Ewing sarcoma (ES) survivors with great interest because, with improving treatments, more and more patients are surviving this disease. It is interesting… read more here.
Keywords: risk; smns; sarcoma survivors; cohort ... See more keywords
SARC025 arms 1 and 2: A phase 1 study of the poly(ADP‐ribose) polymerase inhibitor niraparib with temozolomide or irinotecan in patients with advanced Ewing sarcoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer"
DOI: 10.1002/cncr.33349
Abstract: In preclinical Ewing sarcoma (ES) models, poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors were identified as a potential therapeutic strategy with synergy in combination with cytotoxic agents. This study evaluated the safety and dosing of the… read more here.
Keywords: ribose polymerase; ewing sarcoma; inhibitor niraparib;
Adamantinoma‐like Ewing sarcoma of the parotid gland: Cytopathologic findings and differential diagnosis
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DOI: 10.1002/dc.23829
Abstract: Adamantinoma‐like Ewing sarcoma (AES) is a rare variant of Ewing sarcoma family of tumors (EFTs), primarily affecting bone and soft tissue. AES has mixed features of Ewing sarcoma (ES)/primitive neuroectodermal tumor (PNET) and adamantinoma with… read more here.
Keywords: sarcoma; parotid gland; like ewing; adamantinoma like ... See more keywords
Fine‐needle aspiration cytology of adamantinoma‐like Ewing sarcoma: An unusual parotid tumor
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.25061
Abstract: Adamantinoma‐like Ewing sarcoma (ALES) is a histological subtype of Ewing sarcoma that demonstrates the morphological and immunohistochemical features of the latter, harbors the EWSR1::FLI1 gene fusion, and additionally demonstrates complex epithelial differentiation on morphology and… read more here.
Keywords: adamantinoma like; ewing sarcoma; fine needle; like ewing ... See more keywords
Ewing sarcoma and related FET family translocation‐associated round cell tumors: A century of clinical and scientific progress
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.1002/gcc.23050
Abstract: The year 2021 marked the centenary of the first publication of a cancer termed diffuse endothelioma of bone by James Ewing. Its unique features were apparent even in the first case series he described. This… read more here.
Keywords: cell; family; sarcoma; ewing sarcoma ... See more keywords
miR‐130b directly targets ARHGAP1 to drive activation of a metastatic CDC42‐PAK1‐AP1 positive feedback loop in Ewing sarcoma
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DOI: 10.1002/ijc.30909
Abstract: Ewing Sarcoma (ES) is a highly aggressive bone tumor with peak incidence in the adolescent population. It has a high propensity to metastasize, which is associated with dismal survival rates of approximately 25%. To further… read more here.
Keywords: cdc42; ewing sarcoma; activation; mir 130b ... See more keywords
Late toxicity comparison of alkylating‐based maintenance regimen with cyclophosphamide (VAC) vs ifosfamide (VAI) in Ewing sarcoma survivors treated in the randomized clinical trial Euro‐EWING99‐R1 in France
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34326
Abstract: In Euro‐EWING99‐R1 randomized trial, cyclophosphamide was shown to be noninferior to ifosfamide in the consolidation of standard‐risk Ewing sarcoma (SR‐EWS) after a common induction with VIDE (vincristine‐ifosfamide‐doxorubicin‐etoposide). We present the results of the late effects… read more here.
Keywords: ewing sarcoma; toxicity; euro ewing99; vai ... See more keywords
Analysis of Regulatory DNA Sequences by Dual-Luciferase Reporter Assays in Ewing Sarcoma.
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DOI: 10.1007/978-1-0716-1020-6_10
Abstract: Reporter gene assays allow for examining the influence of regulatory DNA sequences on the transcription of target genes. In Ewing sarcoma, the study of these DNA sequences is especially paramount for its main driver mutation… read more here.
Keywords: reporter; regulatory dna; dna sequences; dna ... See more keywords