Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma
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DOI: 10.1158/1078-0432.ccr-16-2185
Abstract: Purpose: Ewing sarcoma (EWS) is a devastating soft tissue sarcoma affecting predominantly young individuals. Tyrosine kinases (TK) and associated pathways are continuously activated in many malignancies, including EWS; these enzymes provide candidate therapeutic targets. Experimental… read more here.
Keywords: ews cells; syk myc; malat1; syk ... See more keywords
Abstract 4399: Exploring the postmitotic roles of STAG2 mutations in solid tumors
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DOI: 10.1158/1538-7445.sabcs18-4399
Abstract: Mutations in the cohesin complex are associated with cancer, in particular Ewing’s Sarcoma (EWS) and bladder cancer. The STAG2 subunit of cohesin is essential for its loading onto chromatin and proper function of the complex.… read more here.
Keywords: stag2; ews cells; cancer; ewsr1 fli1 ... See more keywords