One oncogene, several vulnerabilities: EWS/FLI targeted therapies for Ewing sarcoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone Oncology"
DOI: 10.1016/j.jbo.2021.100404
Abstract: Highlights • EWS/FLI is the driver oncogene of Ewing sarcoma.• EWS-FLI driven transcription yields numerous therapeutic vulnerabilities.• The intrinsic cellular stress of dysregulated transcription leads to additional therapeutic vulnerabilities.• A number of compounds targeting various… read more here.
Keywords: oncogene several; several vulnerabilities; ews fli; ewing sarcoma ... See more keywords
Abstract 1118: Synthetic lethality of CDK12 inhibition in tumors with EWS/FLI rearrangements
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1118
Abstract: THZ1 is a potent, covalent inhibitor of the transcriptional CDKs, CDK7/12/13. Chemical genomic profiling of THZ1 across >1,000 diverse cancer cell lines revealed that EWS/FLI- rearranged Ewing sarcoma cells were remarkably sensitive to this molecule.… read more here.
Keywords: cdk12 inhibition; ewing sarcoma; cdk12; ews fli ... See more keywords
Abstract 1162: The evaluation of INCB059872, an FAD-directed covalent inhibitor of LSD1, in preclinical models of Ewing sarcoma
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DOI: 10.1158/1538-7445.am2017-1162
Abstract: Ewing sarcoma is a rare bone cancer affecting predominantly children. The chromosomal translocation of chromosomes 11 and 22 results in the EWS/FLI gene fusion oncoprotein that is associated with ~85% of Ewing sarcoma cases. The… read more here.
Keywords: fad directed; ews fli; incb059872; ewing sarcoma ... See more keywords
Identification of two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma
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DOI: 10.1371/journal.pone.0186275
Abstract: Ewing sarcoma is a bone malignancy of children and young adults, frequently harboring the EWS/FLI chromosomal translocation. The resulting fusion protein is an aberrant transcription factor that uses highly repetitive GGAA-containing elements (microsatellites) to activate… read more here.
Keywords: binding gene; ews fli; fli binding; ggaa microsatellites ... See more keywords