SPOP and OTUD7A Control EWS–FLI1 Protein Stability to Govern Ewing Sarcoma Growth
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Science"
DOI: 10.1002/advs.202004846
Abstract: Abstract Chromosomal translocation results in development of an Ewing sarcoma breakpoint region 1‐Friend leukemia integration 1 (EWS–FLI1) fusion oncogene in the majority of Ewing sarcoma. The persistent dependence of the tumor for this oncoprotein points… read more here.
Keywords: ews fli1; sarcoma growth; fli1 protein; ewing sarcoma ... See more keywords
Cell cycle arrest and apoptosis are early events in radiosensitization of EWS::FLI1+ Ewing sarcoma cells by Mithramycin A.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of radiation biology"
DOI: 10.1080/09553002.2023.2188930
Abstract: PURPOSE The oncogenic fusion protein EWS::FLI1 is an attractive therapeutic target in Ewing sarcoma (ES). Mithramycin A (MithA) is a potent and specific inhibitor of EWS::FLI1 that can selectively radiosensitize ES cells through transcriptional inhibition… read more here.
Keywords: apoptosis; ewing sarcoma; mitha; cell cycle ... See more keywords
Abstract 2560: Identification and characterization of EWS-FLI1 binding partners in Ewing sarcoma cell lines
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-2560
Abstract: Ewing sarcoma (ES) is characterized by a reciprocal translocation t(11;22) that results in a fusion of the EWSR1 and FLI1 genes (EWS-FLI). The objective of this study is to identify protein binding partners of the… read more here.
Keywords: ews fli1; cell lines; control; binding partners ... See more keywords
Abstract 694: TK-216: a novel, first-in-class, small molecule inhibitor of EWS-FLI1 in early clinical development, for the treatment of Ewing Sarcoma
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-694
Abstract: One of the most significant challenges in creating more potent, less toxic treatments for patients is to identify new cancer therapeutic targets that distinguish the malignant from normal cells. EWS-FLI1 is a well-established Ewing sarcoma… read more here.
Keywords: ews fli1; 216 novel; novel first; ewing sarcoma ... See more keywords
Abstract LB-047: Optimizing the trabectedin-mediated inhibition of EWS-FLI1 activity by schedule and fusion type
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-lb-047
Abstract: BACKGROUND: Ewing sarcoma (ES) is a pediatric malignancy characterized by the EWS-FLI1 transcription factor. ES tumors require the continuous transcriptional activity of EWS-FLI1 for the oncogenic phenotype, regardless of fusion type, which makes EWS-FLI1 an… read more here.
Keywords: ews fli1; trabectedin; schedule; type ... See more keywords
Abstract 1632: Suppression of EWS-FLI1 transcription using a combination therapy of mithramycin and cyclin-dependent kinase 9 inhibition
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1632
Abstract: Background: Ewing sarcoma (ES) is a pediatric soft tissue tumor with a poor prognosis. ES is dependent on the presence and activity of the oncogenic transcription factor, EWS-FLI1, that dysregulates gene expression at hundreds of… read more here.
Keywords: ews fli1; combination therapy; transcription; fli1 driven ... See more keywords
Abstract 1467: A novel screening model to identify EWS::FLI1 regulators and their consequences on Ewing sarcoma plasticity
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1467
Abstract: Ewing sarcoma (ES) is a rare, highly aggressive cancer of the bone and soft tissues that mainly affects children and young adults. The most common driver of ES is a chromosomal translocation between the EWSR1… read more here.
Keywords: ewing sarcoma; model identify; screening model; ef1 ... See more keywords
Abstract IA04: Targeting the expression of EWS-FLI1
Sign Up to like & getrecommendations! Published in 2018 at "Genomics"
DOI: 10.1158/1557-3265.sarcomas17-ia04
Abstract: Post-translational modifications (PTMs) of transcription factors represent potential therapeutic targets for a variety of diseases, including cancer. In the majority of cases of the bone and soft tissue tumor Ewing sarcoma (ES), a chromosomal translocation,… read more here.
Keywords: ews fli1; fli1 abstract; expression ews; abstract ia04 ... See more keywords
AT-hook DNA-binding motif-containing protein one knockdown downregulates EWS-FLI1 transcriptional activity in Ewing’s sarcoma cells
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0269077
Abstract: Ewing’s sarcoma is the second most common bone malignancy in children or young adults and is caused by an oncogenic transcription factor by a chromosomal translocation between the EWSR1 gene and the ETS transcription factor… read more here.
Keywords: transcriptional activity; ewing sarcoma; knockdown; sarcoma cells ... See more keywords
IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing’s sarcoma
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.24467
Abstract: Ewing's sarcoma (ES) is the second-most frequent pediatric bone tumor. Chromosomal translocation t(11;22)(q24:q12) results in the formation of EWS/FLI1 gene fusion, which is detected in approximately 90% of tumors of the Ewing family. Several transcriptome… read more here.
Keywords: ews fli1; ire1 xbp1; tumor; xbp1 inhibitors ... See more keywords
Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25760
Abstract: Ewing sarcoma (EwS) is an aggressive pediatric bone cancer in need of more effective therapies than currently available. Most research into novel targeted therapeutic approaches is focused on the fusion oncogene EWSR1-FLI1, which is the… read more here.
Keywords: ews fli1; differential sensitivities; ewing sarcoma; sensitivities ewing ... See more keywords