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   Articles with "ews fli1" as a keyword



Hijacking the BAF complex: the mechanistic interplay of ARID1A and EWS::FLI1 in Ewing sarcoma

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recommendations! Published in 2024 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13742

Abstract: Ewing sarcoma, an aggressive pediatric cancer, is driven by the EWS::FLI1 fusion protein, which disrupts gene expression by hijacking the BAF chromatin remodeling complex. Central to this mechanism is the formation of biomolecular condensates, mediated… read more here.

Keywords: ewing sarcoma; baf complex; hijacking baf; baf ... See more keywords
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SPOP and OTUD7A Control EWS–FLI1 Protein Stability to Govern Ewing Sarcoma Growth

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recommendations! Published in 2021 at "Advanced Science"

DOI: 10.1002/advs.202004846

Abstract: Abstract Chromosomal translocation results in development of an Ewing sarcoma breakpoint region 1‐Friend leukemia integration 1 (EWS–FLI1) fusion oncogene in the majority of Ewing sarcoma. The persistent dependence of the tumor for this oncoprotein points… read more here.

Keywords: ews fli1; sarcoma growth; fli1 protein; ewing sarcoma ... See more keywords

(GGAA)3-Based TF-PROTACs Enable Targeted Degradation of ETV6 to Inhibit Ewing Sarcoma Growth.

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recommendations! Published in 2025 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.4c18484

Abstract: Ewing sarcoma is a rare pediatric cancer primarily driven by the EWS::FLI1 oncofusion transcription factor. Despite being an ideal drug target, EWS::FLI1 has proven challenging to inhibit with conventional approaches. Recent studies identified ETV6 as… read more here.

Keywords: ewing sarcoma; sarcoma growth; ggaa; ews fli1 ... See more keywords

Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling

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recommendations! Published in 2024 at "Oncogene"

DOI: 10.1038/s41388-024-03199-7

Abstract: Ewing sarcoma (ES) is characterized by EWS::FLI1 or EWS::ERG fusion proteins. Knowing that ion channels are involved in tumorigenesis, this work aimed to study the involvement of the KCNN1 gene, which encodes the SK1 potassium… read more here.

Keywords: kcnn1; cell proliferation; calcium; expression ... See more keywords
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Cell cycle arrest and apoptosis are early events in radiosensitization of EWS::FLI1+ Ewing sarcoma cells by Mithramycin A.

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recommendations! Published in 2023 at "International journal of radiation biology"

DOI: 10.1080/09553002.2023.2188930

Abstract: PURPOSE The oncogenic fusion protein EWS::FLI1 is an attractive therapeutic target in Ewing sarcoma (ES). Mithramycin A (MithA) is a potent and specific inhibitor of EWS::FLI1 that can selectively radiosensitize ES cells through transcriptional inhibition… read more here.

Keywords: apoptosis; ewing sarcoma; mitha; cell cycle ... See more keywords

Abstract 2560: Identification and characterization of EWS-FLI1 binding partners in Ewing sarcoma cell lines

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recommendations! Published in 2017 at "Cancer Research"

DOI: 10.1158/1538-7445.am2017-2560

Abstract: Ewing sarcoma (ES) is characterized by a reciprocal translocation t(11;22) that results in a fusion of the EWSR1 and FLI1 genes (EWS-FLI). The objective of this study is to identify protein binding partners of the… read more here.

Keywords: ews fli1; cell lines; control; binding partners ... See more keywords

Abstract 694: TK-216: a novel, first-in-class, small molecule inhibitor of EWS-FLI1 in early clinical development, for the treatment of Ewing Sarcoma

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recommendations! Published in 2017 at "Cancer Research"

DOI: 10.1158/1538-7445.am2017-694

Abstract: One of the most significant challenges in creating more potent, less toxic treatments for patients is to identify new cancer therapeutic targets that distinguish the malignant from normal cells. EWS-FLI1 is a well-established Ewing sarcoma… read more here.

Keywords: ews fli1; 216 novel; novel first; ewing sarcoma ... See more keywords

Abstract LB-047: Optimizing the trabectedin-mediated inhibition of EWS-FLI1 activity by schedule and fusion type

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recommendations! Published in 2017 at "Cancer Research"

DOI: 10.1158/1538-7445.am2017-lb-047

Abstract: BACKGROUND: Ewing sarcoma (ES) is a pediatric malignancy characterized by the EWS-FLI1 transcription factor. ES tumors require the continuous transcriptional activity of EWS-FLI1 for the oncogenic phenotype, regardless of fusion type, which makes EWS-FLI1 an… read more here.

Keywords: ews fli1; trabectedin; schedule; type ... See more keywords

Abstract 1632: Suppression of EWS-FLI1 transcription using a combination therapy of mithramycin and cyclin-dependent kinase 9 inhibition

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recommendations! Published in 2018 at "Cancer Research"

DOI: 10.1158/1538-7445.am2018-1632

Abstract: Background: Ewing sarcoma (ES) is a pediatric soft tissue tumor with a poor prognosis. ES is dependent on the presence and activity of the oncogenic transcription factor, EWS-FLI1, that dysregulates gene expression at hundreds of… read more here.

Keywords: ews fli1; combination therapy; transcription; fli1 driven ... See more keywords

Abstract 1467: A novel screening model to identify EWS::FLI1 regulators and their consequences on Ewing sarcoma plasticity

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-1467

Abstract: Ewing sarcoma (ES) is a rare, highly aggressive cancer of the bone and soft tissues that mainly affects children and young adults. The most common driver of ES is a chromosomal translocation between the EWSR1… read more here.

Keywords: ewing sarcoma; model identify; screening model; ef1 ... See more keywords

Abstract 3033: Oncogenic ETS transcription factors avoid repression by EZH2 and FOXO1 in prostate cancer and Ewing sarcoma

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.am2024-3033

Abstract: ETS transcription factors play roles throughout development, aiding in hematopoiesis, blood vessel formation and cell fate. The ETS family is composed of 28 members, all of which share an ETS DNA-binding domain. Chromosomal rearrangements that… read more here.

Keywords: cancer; oncogenic ets; prostate cancer; ewing sarcoma ... See more keywords