Validation of PRKCB Immunohistochemistry as a Biomarker for the Diagnosis of Ewing Sarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Fetal and Pediatric Pathology"
DOI: 10.1080/15513815.2022.2117579
Abstract: Abstract Background: Ewing sarcoma (ES) can be confirmed by identifying the EWSR1-FLI1 fusion transcript. This study is to investigate whether immunostaining (IHC) of PRKCB—a protein directly regulated by EWSR1-FLI1 is a surrogate maker for diagnosing… read more here.
Keywords: ewing sarcoma; ewsr1; validation prkcb; fli1 fusion ... See more keywords
Ewing Sarcoma and Atypical Teratoid Rhabdoid Tumor
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric and Developmental Pathology"
DOI: 10.1177/1093526617698599
Abstract: Ewing sarcoma (ES) and atypical teratoid rhabdoid tumor (ATRT) are high-grade malignancies of childhood, each of which is associated with genetic abnormalities on chromosome 22. ES is typically characterized by rearrangement of the EWSR1 locus… read more here.
Keywords: rhabdoid tumor; ewsr1; ewing sarcoma; sarcoma atypical ... See more keywords
Different genomic profiling of sarcoma between Western and Chinese population.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.e23532
Abstract: e23532 Background: Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. The clinical presentation and gene mutations in different subtypes are often atypical, and the profile of gene mutations vary widely. Meanwhile… read more here.
Keywords: sarcoma; genomic profiling; ewsr1; cohort ... See more keywords
Complex/cryptic EWSR1::FLI1/ERG Gene Fusions and 1q Jumping Translocation in Pediatric Ewing Sarcomas
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14061139
Abstract: Ewing sarcomas (ES) are rare small round cell sarcomas often affecting children and characterized by gene fusions involving one member of the FET family of genes (usually EWSR1) and a member of the ETS family… read more here.
Keywords: complex cryptic; cryptic ewsr1; translocation; ewsr1 ... See more keywords
Splice variants denote differences between a cancer stem cell side population of EWSR1-ERG-based Ewing sarcoma cells, its main population and EWSR1-FLI-based cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2022.5094
Abstract: Ewing sarcoma is a challenging cancer entity, which, besides the characteristic presence of a fusion gene, is driven by multiple alternative splicing events. So far, splice variants in Ewing sarcoma cells were mainly analyzed for… read more here.
Keywords: ewing sarcoma; population ewsr1; population; ewsr1 erg ... See more keywords