Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.049
Abstract: EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a cascade of signaling events leading to cell transformation. However, it remains elusive how genetically homogeneous EwS cells can drive the heterogeneity of transcriptional programs.… read more here.
Keywords: ewsr1 fli1; transcriptional programs; heterogeneity; ewing sarcoma ... See more keywords
Validation of PRKCB Immunohistochemistry as a Biomarker for the Diagnosis of Ewing Sarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Fetal and Pediatric Pathology"
DOI: 10.1080/15513815.2022.2117579
Abstract: Abstract Background: Ewing sarcoma (ES) can be confirmed by identifying the EWSR1-FLI1 fusion transcript. This study is to investigate whether immunostaining (IHC) of PRKCB—a protein directly regulated by EWSR1-FLI1 is a surrogate maker for diagnosing… read more here.
Keywords: ewing sarcoma; ewsr1; validation prkcb; fli1 fusion ... See more keywords
PO-136 SOX2 is a novel biomarker for high-risk ewing sarcoma
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.177
Abstract: Introduction Ewing sarcoma (EwS) is the second most common paediatric bone-associated cancer, which may originate from mesenchymal stem cells (MSCs). It is characterised by specific fusion oncogenes involving the EWSR1 gene and variable members of… read more here.
Keywords: ewsr1 fli1; high risk; biomarker high; ewing sarcoma ... See more keywords
Abstract 4399: Exploring the postmitotic roles of STAG2 mutations in solid tumors
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-4399
Abstract: Mutations in the cohesin complex are associated with cancer, in particular Ewing’s Sarcoma (EWS) and bladder cancer. The STAG2 subunit of cohesin is essential for its loading onto chromatin and proper function of the complex.… read more here.
Keywords: stag2; ews cells; cancer; ewsr1 fli1 ... See more keywords
MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1099550
Abstract: Ewing sarcoma is a cancer of children and young adults characterized by the critical translocation-associated fusion oncoprotein EWSR1::FLI1. EWSR1::FLI1 targets characteristic genetic loci where it mediates aberrant chromatin and the establishment of de novo enhancers.… read more here.
Keywords: chromatin; chromatin accessibility; ewsr1 fli1; ewing sarcoma ... See more keywords
Regulation of Metastasis in Ewing Sarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14194902
Abstract: Simple Summary Ewing sarcoma (EwS) is the second most common bone and soft tissue cancer which mainly happens in children and adolescents. Currently, EwS patients are treated with a combination of surgery, radiation, and interval… read more here.
Keywords: metastasis; regulation metastasis; ewing sarcoma; metastasis ewing ... See more keywords
Regulation of EWSR1-FLI1 Function by Post-Transcriptional and Post-Translational Modifications
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15020382
Abstract: Simple Summary Ewing sarcoma is a malignant pediatric bone cancer currently lacking targeted therapy. In the US there are ~200 patients diagnosed each year and relapse is associated with resistance to the standard-of-care chemotherapy. Thus,… read more here.
Keywords: ewing sarcoma; transcriptional post; ewsr1 fli1; post transcriptional ... See more keywords
Complex/cryptic EWSR1::FLI1/ERG Gene Fusions and 1q Jumping Translocation in Pediatric Ewing Sarcomas
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14061139
Abstract: Ewing sarcomas (ES) are rare small round cell sarcomas often affecting children and characterized by gene fusions involving one member of the FET family of genes (usually EWSR1) and a member of the ETS family… read more here.
Keywords: complex cryptic; cryptic ewsr1; translocation; ewsr1 ... See more keywords